Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Cyclin-dependent kinase 8' and Ligand = 'BDBM50155239'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50155239 (CHEMBL3775935) Show SMILES Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)C(=O)N2CCCC2)cc1 Show InChI InChI=1S/C23H23N5O/c1-27-15-19(14-24-27)17-6-4-16(5-7-17)12-22-20-13-18(8-9-21(20)25-26-22)23(29)28-10-2-3-11-28/h4-9,13-15H,2-3,10-12H2,1H3,(H,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Inhibition of CDK8 (unknown origin) expressed in 7dF3 clone of human HEK293 cells preincubated for 2 hrs followed by addition of beta-estradiol by lu...				Bioorg Med Chem Lett 26: 1443-51 (2016) Article DOI: 10.1016/j.bmcl.2016.01.062 BindingDB Entry DOI: 10.7270/Q2NZ89G6
					More data for this Ligand-Target Pair