BindingDB PrimarySearch

Found 13 hits Enz. Inhib. hit(s) with Target = 'D(2) dopamine receptor' and Ligand = 'BDBM50007534'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50007534 (3-Bromo-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2-hy...) Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)ccc1OC Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Astra Research Centre AB Curated by ChEMBL					Assay Description Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2				J Med Chem 33: 1155-63 (1990) BindingDB Entry DOI: 10.7270/Q24X58DR
Astra Research Centre AB Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50007534 (3-Bromo-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2-hy...) Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)ccc1OC Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Astra Research Centre AB Curated by ChEMBL					Assay Description Inhibition of [3H]raclopride binding to rat striatal dopamine receptor D2				J Med Chem 34: 948-55 (1991) BindingDB Entry DOI: 10.7270/Q2GT5NS9
Astra Research Centre AB Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50007534 (3-Bromo-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2-hy...) Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)ccc1OC Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Astra Läkemedel AB Curated by PDSP K_i Database									Acta Pharmacol Toxicol (Copenh) 58: 61-70 (1986) Article DOI: 10.1111/j.1600-0773.1986.tb00071.x BindingDB Entry DOI: 10.7270/Q2PG1Q7V
Astra Läkemedel AB Curated by PDSP K_i Database					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50007534 (3-Bromo-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2-hy...) Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)ccc1OC Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Astra Läkemedel AB Curated by PDSP K_i Database									Acta Pharmacol Toxicol (Copenh) 58: 61-70 (1986) Article DOI: 10.1111/j.1600-0773.1986.tb00071.x BindingDB Entry DOI: 10.7270/Q2PG1Q7V
Astra Läkemedel AB Curated by PDSP K_i Database					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50007534 (3-Bromo-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2-hy...) Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)ccc1OC Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Astra Läkemedel AB Curated by PDSP K_i Database									Acta Pharmacol Toxicol (Copenh) 58: 61-70 (1986) Article DOI: 10.1111/j.1600-0773.1986.tb00071.x BindingDB Entry DOI: 10.7270/Q2PG1Q7V
Astra Läkemedel AB Curated by PDSP K_i Database					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50007534 (3-Bromo-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2-hy...) Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)ccc1OC Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
University of Mazandaran Curated by ChEMBL					Assay Description Antagonist activity at dopamine D2 receptor				Eur J Med Chem 45: 4856-62 (2010) Article DOI: 10.1016/j.ejmech.2010.07.056 BindingDB Entry DOI: 10.7270/Q2833T8S
University of Mazandaran Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50007534 (3-Bromo-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2-hy...) Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)ccc1OC Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Astra Research Centre AB Curated by ChEMBL					Assay Description In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes.				J Med Chem 33: 1155-63 (1990) BindingDB Entry DOI: 10.7270/Q24X58DR
Astra Research Centre AB Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50007534 (3-Bromo-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2-hy...) Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)ccc1OC Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Astra Research Centre AB Curated by ChEMBL					Assay Description The affinity for the Dopamine receptor D2 was assessed by the inhibition of [3H]-spiperone binding in rat striatal membranes in vitro.				J Med Chem 33: 2305-9 (1990) BindingDB Entry DOI: 10.7270/Q29P30MH
Astra Research Centre AB Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50007534 (3-Bromo-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2-hy...) Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)ccc1OC Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Astra Research Centre AB Curated by ChEMBL					Assay Description Inhibition of [3H]raclopride binding to rat striatal dopamine receptor D2				J Med Chem 34: 948-55 (1991) BindingDB Entry DOI: 10.7270/Q2GT5NS9
Astra Research Centre AB Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50007534 (3-Bromo-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2-hy...) Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)ccc1OC Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Burroughs Wellcome Co. Curated by ChEMBL					Assay Description Tested in vitro for inhibition of [3H]spiperone binding to dopamine receptor D2				J Med Chem 36: 3417-23 (1993) BindingDB Entry DOI: 10.7270/Q2S75GZD
Burroughs Wellcome Co. Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50007534 (3-Bromo-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2-hy...) Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)ccc1OC Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro binding affinity at Dopamine receptor D2 in rat by displacing [3H]- spiperone from rat striatal membrane				J Med Chem 28: 1263-9 (1985) BindingDB Entry DOI: 10.7270/Q2QZ2BHD
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50007534 (3-Bromo-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2-hy...) Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)ccc1OC Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro binding affinity at Dopamine receptor D2 in rat by displacing [3H]- spiperone from rat striatal membrane				J Med Chem 28: 1263-9 (1985) BindingDB Entry DOI: 10.7270/Q2QZ2BHD
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50007534 (3-Bromo-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2-hy...) Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)ccc1OC Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description In vivo inhibitory activity of the compound against dopamine (D2) receptor in rat caudate-putamen tissue				Bioorg Med Chem Lett 13: 4015-7 (2003) BindingDB Entry DOI: 10.7270/Q27M07BC
Yale University Curated by ChEMBL					More data for this Ligand-Target Pair