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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'DNA topoisomerase 4 subunit A/B' and Ligand = 'BDBM50440301'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 4 subunit A/B


(Staphylococcus aureus)		BDBM50440301
PNG
(CHEMBL2424878)
Show SMILES COc1ccc2ncc(F)c([C@@H](O)[C@H](O)[C@@H]3CC[C@H](CO3)NCc3cc4SCCOc4nn3)c2n1 |r|
Show InChI InChI=1S/C23H26FN5O5S/c1-32-18-5-3-15-20(27-18)19(14(24)10-26-15)22(31)21(30)16-4-2-12(11-34-16)25-9-13-8-17-23(29-28-13)33-6-7-35-17/h3,5,8,10,12,16,21-22,25,30-31H,2,4,6-7,9,11H2,1H3/t12-,16+,21-,22-/m1/s1
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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 8.00E+3n/an/an/an/an/an/a



Actelion Pharmaceuticals Ltd

Curated by ChEMBL


Assay Description
Inhibition of wild type Staphylococcus aureus ATCC 29213 topoisomerase-4 subunit 2GrlA/2GrlB assessed as pBR322 relaxation after 1 hr

J Med Chem 56: 7396-415 (2013)


Article DOI: 10.1021/jm400963y
BindingDB Entry DOI: 10.7270/Q2HT2QRV
More data for this
Ligand-Target Pair