Found 2 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM50438720' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50438720
(CHEMBL2414655)Show SMILES CN1CCN(CC1=O)C(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O |r,wU:14.18,wD:11.11,(42.23,-35.63,;41.19,-36.81,;41.69,-38.27,;40.68,-39.42,;39.19,-39.16,;38.68,-37.67,;39.69,-36.51,;39.19,-35.03,;38.15,-40.35,;38.64,-41.8,;36.64,-40.05,;35.61,-41.23,;34.1,-40.93,;33.09,-42.09,;33.59,-43.58,;35.09,-43.84,;36.1,-42.68,;32.56,-44.76,;31.05,-44.46,;30.03,-45.62,;30.54,-47.1,;32.04,-47.37,;33.06,-46.22,;29.51,-48.27,;30.13,-49.7,;29.4,-51.08,;27.87,-51.36,;26.7,-50.34,;25.32,-51.07,;24.01,-50.24,;24.07,-48.69,;25.44,-47.96,;25.5,-46.4,;26.75,-48.79,;28.01,-47.87,;27.73,-46.34,)| Show InChI InChI=1S/C26H32N6O4/c1-30-10-11-31(15-22(30)34)21(33)14-17-2-4-18(5-3-17)19-6-8-20(9-7-19)32-12-13-36-25-23(26(32)35)24(27)28-16-29-25/h6-9,16-18H,2-5,10-15H2,1H3,(H2,27,28,29)/t17-,18- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry |
Bioorg Med Chem 21: 5081-97 (2013)
Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50438720
(CHEMBL2414655)Show SMILES CN1CCN(CC1=O)C(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O |r,wU:14.18,wD:11.11,(42.23,-35.63,;41.19,-36.81,;41.69,-38.27,;40.68,-39.42,;39.19,-39.16,;38.68,-37.67,;39.69,-36.51,;39.19,-35.03,;38.15,-40.35,;38.64,-41.8,;36.64,-40.05,;35.61,-41.23,;34.1,-40.93,;33.09,-42.09,;33.59,-43.58,;35.09,-43.84,;36.1,-42.68,;32.56,-44.76,;31.05,-44.46,;30.03,-45.62,;30.54,-47.1,;32.04,-47.37,;33.06,-46.22,;29.51,-48.27,;30.13,-49.7,;29.4,-51.08,;27.87,-51.36,;26.7,-50.34,;25.32,-51.07,;24.01,-50.24,;24.07,-48.69,;25.44,-47.96,;25.5,-46.4,;26.75,-48.79,;28.01,-47.87,;27.73,-46.34,)| Show InChI InChI=1S/C26H32N6O4/c1-30-10-11-31(15-22(30)34)21(33)14-17-2-4-18(5-3-17)19-6-8-20(9-7-19)32-12-13-36-25-23(26(32)35)24(27)28-16-29-25/h6-9,16-18H,2-5,10-15H2,1H3,(H2,27,28,29)/t17-,18- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi... |
Bioorg Med Chem 21: 5081-97 (2013)
Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG |
More data for this
Ligand-Target Pair | |
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