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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM50438720 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_976374 (CHEMBL2415510) | ||
| IC50 | 170±n/a nM | ||
| Citation |  Dow, RL; Andrews, MP; Li, JC; Michael Gibbs, E; Guzman-Perez, A; Laperle, JL; Li, Q; Mather, D; Munchhof, MJ; Niosi, M; Patel, L; Perreault, C; Tapley, S; Zavadoski, WJ Defining the key pharmacophore elements of PF-04620110: discovery of a potent, orally-active, neutral DGAT-1 inhibitor. Bioorg Med Chem21:5081-97 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Protein | ||
| Mol. Mass.: | 55297.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75907 | ||
| Residue: | 488 | ||
| Sequence: |
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| BDBM50438720 | |||
| n/a | |||
| Name | BDBM50438720 | ||
| Synonyms: | CHEMBL2414655 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H32N6O4 | ||
| Mol. Mass. | 492.5701 | ||
| SMILES | CN1CCN(CC1=O)C(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O |r,wU:14.18,wD:11.11,(42.23,-35.63,;41.19,-36.81,;41.69,-38.27,;40.68,-39.42,;39.19,-39.16,;38.68,-37.67,;39.69,-36.51,;39.19,-35.03,;38.15,-40.35,;38.64,-41.8,;36.64,-40.05,;35.61,-41.23,;34.1,-40.93,;33.09,-42.09,;33.59,-43.58,;35.09,-43.84,;36.1,-42.68,;32.56,-44.76,;31.05,-44.46,;30.03,-45.62,;30.54,-47.1,;32.04,-47.37,;33.06,-46.22,;29.51,-48.27,;30.13,-49.7,;29.4,-51.08,;27.87,-51.36,;26.7,-50.34,;25.32,-51.07,;24.01,-50.24,;24.07,-48.69,;25.44,-47.96,;25.5,-46.4,;26.75,-48.79,;28.01,-47.87,;27.73,-46.34,)| | ||
| Structure | 
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