Found 2 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM50438725' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50438725
(CHEMBL2414652)Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(=O)N4CCCC4)CC3)C(=O)c12 |r,wU:16.16,wD:19.20,(21.03,-46.19,;21.01,-47.73,;19.67,-48.48,;19.65,-50.03,;20.99,-50.81,;22.33,-50.05,;23.52,-51.03,;25.04,-50.71,;25.72,-49.32,;25.04,-47.91,;26.04,-46.71,;27.54,-46.96,;28.51,-45.79,;27.97,-44.32,;26.48,-44.11,;25.51,-45.28,;28.96,-43.12,;28.43,-41.7,;29.4,-40.52,;30.9,-40.74,;31.88,-39.55,;33.4,-39.81,;33.94,-41.25,;34.39,-38.62,;35.93,-38.71,;36.51,-37.26,;35.31,-36.27,;34,-37.1,;31.44,-42.2,;30.46,-43.38,;23.56,-47.57,;23.23,-46.06,;22.34,-48.52,)| Show InChI InChI=1S/C25H31N5O3/c26-23-22-24(28-16-27-23)33-14-13-30(25(22)32)20-9-7-19(8-10-20)18-5-3-17(4-6-18)15-21(31)29-11-1-2-12-29/h7-10,16-18H,1-6,11-15H2,(H2,26,27,28)/t17-,18- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry |
Bioorg Med Chem 21: 5081-97 (2013)
Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50438725
(CHEMBL2414652)Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(=O)N4CCCC4)CC3)C(=O)c12 |r,wU:16.16,wD:19.20,(21.03,-46.19,;21.01,-47.73,;19.67,-48.48,;19.65,-50.03,;20.99,-50.81,;22.33,-50.05,;23.52,-51.03,;25.04,-50.71,;25.72,-49.32,;25.04,-47.91,;26.04,-46.71,;27.54,-46.96,;28.51,-45.79,;27.97,-44.32,;26.48,-44.11,;25.51,-45.28,;28.96,-43.12,;28.43,-41.7,;29.4,-40.52,;30.9,-40.74,;31.88,-39.55,;33.4,-39.81,;33.94,-41.25,;34.39,-38.62,;35.93,-38.71,;36.51,-37.26,;35.31,-36.27,;34,-37.1,;31.44,-42.2,;30.46,-43.38,;23.56,-47.57,;23.23,-46.06,;22.34,-48.52,)| Show InChI InChI=1S/C25H31N5O3/c26-23-22-24(28-16-27-23)33-14-13-30(25(22)32)20-9-7-19(8-10-20)18-5-3-17(4-6-18)15-21(31)29-11-1-2-12-29/h7-10,16-18H,1-6,11-15H2,(H2,26,27,28)/t17-,18- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi... |
Bioorg Med Chem 21: 5081-97 (2013)
Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG |
More data for this
Ligand-Target Pair | |
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