Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM35065'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM35065 (N-acylpolyamine (NAPA) scaffold, 12) Show SMILES COc1ccc(CCCNC(=O)N(CCC(N)=O)CC(CCC(O)=O)N(CC(CCCCN)N(CC(CCC(O)=O)NC(N)=O)C(=O)NCCCC(C)C)C(=O)NCCc2ccc(Br)cc2)cc1 Show InChI InChI=1S/C47H75BrN10O10/c1-33(2)8-6-26-53-46(66)57(30-37(55-44(51)64)17-21-42(60)61)38(10-4-5-25-49)32-58(47(67)54-28-23-35-11-15-36(48)16-12-35)39(18-22-43(62)63)31-56(29-24-41(50)59)45(65)52-27-7-9-34-13-19-40(68-3)20-14-34/h11-16,19-20,33,37-39H,4-10,17-18,21-32,49H2,1-3H3,(H2,50,59)(H,52,65)(H,53,66)(H,54,67)(H,60,61)(H,62,63)(H3,51,55,64)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.6	23
NIH					Assay Description Inhibitory activities of NAPAs were measured by fluorescence anisotropy competition experiments. Protein was incubated with fluorescein-labeled huma...				Bioorg Med Chem 17: 7884-93 (2009) Article DOI: 10.1016/j.bmc.2009.10.032 BindingDB Entry DOI: 10.7270/Q2057D90
					More data for this Ligand-Target Pair