Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM50299823 ((6R,7S)-6,7-bis(4-bromophenyl)-7,11-dihydro-6H-chr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid UniChem Similars | MMDB Article PubMed | 1.23E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by ChEMBL | Assay Description Binding affinity to MDM2 (unknown origin) expressed in Escherichia coli BL21(DE3) after 30 mins by fluorescence polarization assay in presence of P4 ... | Bioorg Med Chem 21: 3982-95 (2013) Article DOI: 10.1016/j.bmc.2012.06.020 BindingDB Entry DOI: 10.7270/Q2QV3NWD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM50299823 ((6R,7S)-6,7-bis(4-bromophenyl)-7,11-dihydro-6H-chr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid UniChem Similars | MMDB Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Inhibition of ligase activity of human MDM2 | J Med Chem 52: 7044-53 (2009) Article DOI: 10.1021/jm900681h BindingDB Entry DOI: 10.7270/Q2ZK5GRQ | |||||||||||
More data for this Ligand-Target Pair |