Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50131841 (CHEMBL3633143) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of EGFR T790M mutant (unknown origin) using Poly (Glu, Tyr)4:1 as substrate by spectrophotometry | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00651 BindingDB Entry DOI: 10.7270/Q2DF6W36 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50131841 (CHEMBL3633143) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health Curated by ChEMBL | Assay Description Inhibition of N-terminal 6His/TEV protease cleavage site-tagged wild type human EGFR using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA | Eur J Med Chem 126: 1107-1117 (2017) Article DOI: 10.1016/j.ejmech.2016.12.006 BindingDB Entry DOI: 10.7270/Q2F47RD5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50131841 (CHEMBL3633143) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 386 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Binding affinity against delta opioid receptor in mouse hot plate test | ACS Med Chem Lett 6: 987-92 (2015) Article DOI: 10.1021/acsmedchemlett.5b00193 BindingDB Entry DOI: 10.7270/Q21C1ZPN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |