Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM50029668 (AZD-9291 | Osimertinib | US10085983, Compound AZD-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | PDB US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | 25 |
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Yangtze River Pharmaceutical Group Co., Ltd. US Patent | Assay Description All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas... | US Patent US10085983 (2018) BindingDB Entry DOI: 10.7270/Q28W3GBG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |