BindingDB PrimarySearch

Found 12 hits Enz. Inhib. hit(s) with Target = 'Estrogen receptor beta' and Ligand = 'BDBM50276802'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Estrogen receptor beta (Homo sapiens (Human))	BDBM50276802 (4-OHT \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	0.249	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Le Centre Hospitalier Universitaire de Qu£bec Curated by ChEMBL					Assay Description Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol)				J Med Chem 40: 2117-22 (1997) Article DOI: 10.1021/jm970095o BindingDB Entry DOI: 10.7270/Q2474DKC
					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM50276802 (4-OHT \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	0.346	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Le Centre Hospitalier Universitaire de Qu£bec Curated by ChEMBL					Assay Description Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanol				J Med Chem 40: 2117-22 (1997) Article DOI: 10.1021/jm970095o BindingDB Entry DOI: 10.7270/Q2474DKC
					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM50276802 (4-OHT \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	3.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research & Development Curated by ChEMBL					Assay Description Binding affinity for human estrogen receptor beta				J Med Chem 48: 2243-7 (2005) Article DOI: 10.1021/jm040154f BindingDB Entry DOI: 10.7270/Q24T6N42
GlaxoSmithKline Research & Development Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM50276802 (4-OHT \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Antagonism of estrogen action in a mammary tumor cell line was assayed via inhibition of MCF-7 cell proliferation stimulated by 10 e-11 M 17-beta-est...				J Med Chem 40: 146-67 (1997) Article DOI: 10.1021/jm9606352 BindingDB Entry DOI: 10.7270/Q2PZ5CKJ
Eli Lilly and Company Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM50276802 (4-OHT \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research & Development Curated by ChEMBL					Assay Description pIC50 for 1 nM estradiol-induced Ishikawa cell proliferation				J Med Chem 48: 2243-7 (2005) Article DOI: 10.1021/jm040154f BindingDB Entry DOI: 10.7270/Q24T6N42
GlaxoSmithKline Research & Development Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM50276802 (4-OHT \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Antagonist effect against 10 pM 17-beta-estradiol induced MCF-7 cell proliferation				Bioorg Med Chem Lett 14: 5103-6 (2004) Article DOI: 10.1016/j.bmcl.2004.07.072 BindingDB Entry DOI: 10.7270/Q25X2CQ6
Eli Lilly and Company Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM50276802 (4-OHT \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Versailles/St. Quentin-en-Yvelines Curated by ChEMBL					Assay Description Anti-estrogenicity for 50% inhibition of the MVLN cell luciferase activity due to 0.1 nM E2 (estradiol)				J Med Chem 40: 1104-11 (1997) Article DOI: 10.1021/jm950624t BindingDB Entry DOI: 10.7270/Q218397P
					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM50276802 (4-OHT \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Free University of Berlin Curated by ChEMBL					Assay Description Inhibition of estradiol induced estrogen receptor transcriptional activation in MCF-7-2a cells				J Med Chem 46: 1484-91 (2003) Article DOI: 10.1021/jm0210562 BindingDB Entry DOI: 10.7270/Q28W3H29
Free University of Berlin Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM50276802 (4-OHT \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Antagonist activity at estrogen receptor alpha/beta in human Ishikawa cells after 72 hrs by alkaline phosphatase assay				J Med Chem 61: 514-534 (2018) Article DOI: 10.1021/acs.jmedchem.6b01917 BindingDB Entry DOI: 10.7270/Q20K2C6G
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM50276802 (4-OHT \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Displacement of fluorescein-labeled estradiol (fluoromone) from human recombinant full-length estrogen receptor beta after 2 hrs by fluorescence pola...				J Med Chem 61: 514-534 (2018) Article DOI: 10.1021/acs.jmedchem.6b01917 BindingDB Entry DOI: 10.7270/Q20K2C6G
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM50276802 (4-OHT \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Antagonist activity as inhibition of 1 nM 17-beta-estradiol stimulated alkaline phosphatase induction in Ishikawa endometrial cells				Bioorg Med Chem Lett 14: 5103-6 (2004) Article DOI: 10.1016/j.bmcl.2004.07.072 BindingDB Entry DOI: 10.7270/Q25X2CQ6
Eli Lilly and Company Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM50276802 (4-OHT \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	0.800	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Agonist activity as alkaline phosphatase induction in Ishikawa endometrial cells compared to E2				Bioorg Med Chem Lett 14: 5103-6 (2004) Article DOI: 10.1016/j.bmcl.2004.07.072 BindingDB Entry DOI: 10.7270/Q25X2CQ6
Eli Lilly and Company Curated by ChEMBL					More data for this Ligand-Target Pair