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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Eukaryotic translation initiation factor 4E' and Ligand = 'BDBM50365103'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50365103
PNG
(CHEMBL1951189)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12 |r|
Show InChI InChI=1S/C21H30N10O21P4/c1-29-5-31(15-9(29)17(37)28-21(23)26-15)19-13(35)11(33)7(49-19)3-47-54(40,41)51-56(44,45)52-55(42,43)50-53(38,39)46-2-6-10(32)12(34)18(48-6)30-4-24-8-14(30)25-20(22)27-16(8)36/h4-7,10-13,18-19,32-35H,2-3H2,1H3,(H9-,22,23,25,26,27,28,36,37,38,39,40,41,42,43,44,45)/p-4/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated mRNA translation in rabbit reticulocyte lysate by luciferase reporter gene assay


Bioorg Med Chem 20: 1699-710 (2012)


Article DOI: 10.1016/j.bmc.2012.01.013
BindingDB Entry DOI: 10.7270/Q2ZW1MC1
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50365103
PNG
(CHEMBL1951189)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12 |r|
Show InChI InChI=1S/C21H30N10O21P4/c1-29-5-31(15-9(29)17(37)28-21(23)26-15)19-13(35)11(33)7(49-19)3-47-54(40,41)51-56(44,45)52-55(42,43)50-53(38,39)46-2-6-10(32)12(34)18(48-6)30-4-24-8-14(30)25-20(22)27-16(8)36/h4-7,10-13,18-19,32-35H,2-3H2,1H3,(H9-,22,23,25,26,27,28,36,37,38,39,40,41,42,43,44,45)/p-4/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated mRNA translation in rabbit reticulocyte lysate pre-incubated for 60 mins prior to mRNA addition by luciferase reporter g...


Bioorg Med Chem 20: 1699-710 (2012)


Article DOI: 10.1016/j.bmc.2012.01.013
BindingDB Entry DOI: 10.7270/Q2ZW1MC1
More data for this
Ligand-Target Pair