Found 3 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 4' and Ligand = 'BDBM438600' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Fibroblast growth factor receptor 4
(Homo sapiens (Human)) | BDBM438600
(US10618902, Compound I-281)Show SMILES COc1cc(OC)c(F)c(c1F)-c1cc2cnc(N[C@@H]3COC[C@@H]3NC(=O)C=C)nc2n(C)c1=O |r,wU:19.19,23.25,(4.49,5.76,;5.82,4.99,;5.82,3.45,;7.16,2.68,;7.16,1.14,;8.49,.37,;9.82,1.14,;5.82,.37,;5.82,-1.17,;4.49,1.14,;4.49,2.68,;3.16,3.45,;3.16,.37,;1.82,1.14,;.49,.37,;-.85,1.14,;-2.18,.37,;-2.18,-1.17,;-3.51,-1.94,;-4.85,-1.17,;-5.01,.36,;-6.51,.68,;-7.28,-.65,;-6.25,-1.8,;-6.57,-3.3,;-8.04,-3.78,;-9.18,-2.75,;-8.36,-5.28,;-9.82,-5.76,;-.85,-1.94,;.49,-1.17,;1.82,-1.94,;1.82,-3.48,;3.16,-1.17,;4.49,-1.94,)| Show InChI InChI=1S/C23H23F2N5O5/c1-5-17(31)27-13-9-35-10-14(13)28-23-26-8-11-6-12(22(32)30(2)21(11)29-23)18-19(24)15(33-3)7-16(34-4)20(18)25/h5-8,13-14H,1,9-10H2,2-4H3,(H,27,31)(H,26,28,29)/t13-,14+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human wild type N-His tagged FGFR4 (460-802) using Y10-Sox as substrate in presence of 250 uM ATP by Omnia kinase method |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.9b00601
BindingDB Entry DOI: 10.7270/Q2CN77NN |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Homo sapiens (Human)) | BDBM438600
(US10618902, Compound I-281)Show SMILES COc1cc(OC)c(F)c(c1F)-c1cc2cnc(N[C@@H]3COC[C@@H]3NC(=O)C=C)nc2n(C)c1=O |r,wU:19.19,23.25,(4.49,5.76,;5.82,4.99,;5.82,3.45,;7.16,2.68,;7.16,1.14,;8.49,.37,;9.82,1.14,;5.82,.37,;5.82,-1.17,;4.49,1.14,;4.49,2.68,;3.16,3.45,;3.16,.37,;1.82,1.14,;.49,.37,;-.85,1.14,;-2.18,.37,;-2.18,-1.17,;-3.51,-1.94,;-4.85,-1.17,;-5.01,.36,;-6.51,.68,;-7.28,-.65,;-6.25,-1.8,;-6.57,-3.3,;-8.04,-3.78,;-9.18,-2.75,;-8.36,-5.28,;-9.82,-5.76,;-.85,-1.94,;.49,-1.17,;1.82,-1.94,;1.82,-3.48,;3.16,-1.17,;4.49,-1.94,)| Show InChI InChI=1S/C23H23F2N5O5/c1-5-17(31)27-13-9-35-10-14(13)28-23-26-8-11-6-12(22(32)30(2)21(11)29-23)18-19(24)15(33-3)7-16(34-4)20(18)25/h5-8,13-14H,1,9-10H2,2-4H3,(H,27,31)(H,26,28,29)/t13-,14+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 (unknown origin) expressed in human Huh7 cells assessed as autophosphorylation after 1 hr incubation measured by Mesoscale discov... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.9b00601
BindingDB Entry DOI: 10.7270/Q2CN77NN |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Homo sapiens (Human)) | BDBM438600
(US10618902, Compound I-281)Show SMILES COc1cc(OC)c(F)c(c1F)-c1cc2cnc(N[C@@H]3COC[C@@H]3NC(=O)C=C)nc2n(C)c1=O |r,wU:19.19,23.25,(4.49,5.76,;5.82,4.99,;5.82,3.45,;7.16,2.68,;7.16,1.14,;8.49,.37,;9.82,1.14,;5.82,.37,;5.82,-1.17,;4.49,1.14,;4.49,2.68,;3.16,3.45,;3.16,.37,;1.82,1.14,;.49,.37,;-.85,1.14,;-2.18,.37,;-2.18,-1.17,;-3.51,-1.94,;-4.85,-1.17,;-5.01,.36,;-6.51,.68,;-7.28,-.65,;-6.25,-1.8,;-6.57,-3.3,;-8.04,-3.78,;-9.18,-2.75,;-8.36,-5.28,;-9.82,-5.76,;-.85,-1.94,;.49,-1.17,;1.82,-1.94,;1.82,-3.48,;3.16,-1.17,;4.49,-1.94,)| Show InChI InChI=1S/C23H23F2N5O5/c1-5-17(31)27-13-9-35-10-14(13)28-23-26-8-11-6-12(22(32)30(2)21(11)29-23)18-19(24)15(33-3)7-16(34-4)20(18)25/h5-8,13-14H,1,9-10H2,2-4H3,(H,27,31)(H,26,28,29)/t13-,14+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene CAR LLC; Sanofi
US Patent
| Assay Description
A 10× stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr... |
US Patent US10618902 (2020)
BindingDB Entry DOI: 10.7270/Q25X2D06 |
More data for this
Ligand-Target Pair | |
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