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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Fibroblast growth factor receptor 4 | ||
| Ligand | BDBM438600 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2075296 (CHEMBL4730830) | ||
| IC50 | 11±n/a nM | ||
| Citation |  Liu, H; Niu, D; Tham Sjin, RT; Dubrovskiy, A; Zhu, Z; McDonald, JJ; Fahnoe, K; Wang, Z; Munson, M; Scholte, A; Barrague, M; Fitzgerald, M; Liu, J; Kothe, M; Sun, F; Murtie, J; Ge, J; Rocnik, J; Harvey, D; Ospina, B; Perron, K; Zheng, G; Shehu, E; D'Agostino, LA Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma. ACS Med Chem Lett11:1899-1904 (2020) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Fibroblast growth factor receptor 4 | |||
| Name: | Fibroblast growth factor receptor 4 | ||
| Synonyms: | CD_antigen: CD334 FGFR4 | FGFR-4 | FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | JTK2 | TKF | ||
| Type: | Protein | ||
| Mol. Mass.: | 87957.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P22455 | ||
| Residue: | 802 | ||
| Sequence: |
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| BDBM438600 | |||
| n/a | |||
| Name | BDBM438600 | ||
| Synonyms: | US10618902, Compound I-281 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H23F2N5O5 | ||
| Mol. Mass. | 487.456 | ||
| SMILES | COc1cc(OC)c(F)c(c1F)-c1cc2cnc(N[C@@H]3COC[C@@H]3NC(=O)C=C)nc2n(C)c1=O |r,wU:19.19,23.25,(4.49,5.76,;5.82,4.99,;5.82,3.45,;7.16,2.68,;7.16,1.14,;8.49,.37,;9.82,1.14,;5.82,.37,;5.82,-1.17,;4.49,1.14,;4.49,2.68,;3.16,3.45,;3.16,.37,;1.82,1.14,;.49,.37,;-.85,1.14,;-2.18,.37,;-2.18,-1.17,;-3.51,-1.94,;-4.85,-1.17,;-5.01,.36,;-6.51,.68,;-7.28,-.65,;-6.25,-1.8,;-6.57,-3.3,;-8.04,-3.78,;-9.18,-2.75,;-8.36,-5.28,;-9.82,-5.76,;-.85,-1.94,;.49,-1.17,;1.82,-1.94,;1.82,-3.48,;3.16,-1.17,;4.49,-1.94,)| | ||
| Structure | 
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