BindingDB PrimarySearch

Found 17 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 4' and Ligand = 'BDBM50065454'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM50065454 (CHEBI:63453 \| CHEMBL3348846) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences (CAS) Curated by ChEMBL					Assay Description Inhibition of recombinant FGFR4 (unknown origin) using (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA				Bioorg Med Chem Lett 26: 2594-9 (2016) Article DOI: 10.1016/j.bmcl.2016.04.028 BindingDB Entry DOI: 10.7270/Q20C4XNM
Chinese Academy of Sciences (CAS) Curated by ChEMBL					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM50065454 (CHEBI:63453 \| CHEMBL3348846) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Institute of Materia Medica Curated by ChEMBL					Assay Description Inhibition of human FGFR4 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA				ACS Med Chem Lett 7: 629-34 (2016) Article DOI: 10.1021/acsmedchemlett.6b00066 BindingDB Entry DOI: 10.7270/Q2P272M2
Shanghai Institute of Materia Medica Curated by ChEMBL					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM50065454 (CHEBI:63453 \| CHEMBL3348846) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Institute of Materia Medica Curated by ChEMBL					Assay Description Inhibition of human FGFR4 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA				ACS Med Chem Lett 7: 629-34 (2016) Article DOI: 10.1021/acsmedchemlett.6b00066 BindingDB Entry DOI: 10.7270/Q2P272M2
Shanghai Institute of Materia Medica Curated by ChEMBL					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM50065454 (CHEBI:63453 \| CHEMBL3348846) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai University Curated by ChEMBL					Assay Description Inhibition of human FGFR4 using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISA				J Med Chem 62: 7473-7488 (2019) Article DOI: 10.1021/acs.jmedchem.9b00510 BindingDB Entry DOI: 10.7270/Q2KP85D8
Shanghai University Curated by ChEMBL					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM50065454 (CHEBI:63453 \| CHEMBL3348846) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01019 BindingDB Entry DOI: 10.7270/Q2FB56MJ
TBA					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM50065454 (CHEBI:63453 \| CHEMBL3348846) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	165	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Institute of Materia Medica Curated by ChEMBL					Assay Description Inhibition of human FGFR4				ACS Med Chem Lett 7: 629-34 (2016) Article DOI: 10.1021/acsmedchemlett.6b00066 BindingDB Entry DOI: 10.7270/Q2P272M2
Shanghai Institute of Materia Medica Curated by ChEMBL					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM50065454 (CHEBI:63453 \| CHEMBL3348846) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	165	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of FGFR4 (unknown origin)				J Med Chem 61: 9085-9104 (2018) Article DOI: 10.1021/acs.jmedchem.7b01843 BindingDB Entry DOI: 10.7270/Q2RR22N4
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM50065454 (CHEBI:63453 \| CHEMBL3348846) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	165	n/a	n/a	n/a	n/a	n/a	n/a
The First Affiliated Hospital of Zhengzhou University Curated by ChEMBL					Assay Description Inhibition of recombinant human FGFR4 in presence of ATP				Eur J Med Chem 126: 476-490 (2017) Article DOI: 10.1016/j.ejmech.2016.11.052 BindingDB Entry DOI: 10.7270/Q2445PQT
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM50065454 (CHEBI:63453 \| CHEMBL3348846) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	165	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Institute of Materia Medica Curated by ChEMBL					Assay Description Inhibition of human FGFR4				ACS Med Chem Lett 7: 629-34 (2016) Article DOI: 10.1021/acsmedchemlett.6b00066 BindingDB Entry DOI: 10.7270/Q2P272M2
Shanghai Institute of Materia Medica Curated by ChEMBL					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM50065454 (CHEBI:63453 \| CHEMBL3348846) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	165	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2020.112990 BindingDB Entry DOI: 10.7270/Q2WD44HQ
TBA					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM50065454 (CHEBI:63453 \| CHEMBL3348846) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	165	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science& Technology Curated by ChEMBL					Assay Description Inhibition of recombinant human FGFR4				J Med Chem 59: 6690-708 (2016) Article DOI: 10.1021/acs.jmedchem.6b00056 BindingDB Entry DOI: 10.7270/Q2474CT3
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Mus musculus)	BDBM50065454 (CHEBI:63453 \| CHEMBL3348846) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	348	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of FGFR4 in mouse BAF3 cells assessed as reduction in cell viability incubated for 2 days by cell proliferation assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01019 BindingDB Entry DOI: 10.7270/Q2FB56MJ
TBA					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Mus musculus)	BDBM50065454 (CHEBI:63453 \| CHEMBL3348846) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	519	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01019 BindingDB Entry DOI: 10.7270/Q2FB56MJ
TBA					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM50065454 (CHEBI:63453 \| CHEMBL3348846) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	660	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human FGFR4 (445 to 753 residues) expressed in Escherichia coli BL21 (DE3) by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00174 BindingDB Entry DOI: 10.7270/Q2P84GS6
TBA					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM50065454 (CHEBI:63453 \| CHEMBL3348846) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
Health Science Center Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of FGFR4 (unknown origin) after 90 mins by TR-FRET assay				Bioorg Med Chem Lett 25: 1556-60 (2015) Article DOI: 10.1016/j.bmcl.2015.02.010 BindingDB Entry DOI: 10.7270/Q2NP262J
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM50065454 (CHEBI:63453 \| CHEMBL3348846) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	5.10E+4	n/a	n/a
TBA					Assay Description Inhibition of wild-type FGFR4 C477A mutant (unknown origin) assessed as ratio of Kinact to Ki				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01019 BindingDB Entry DOI: 10.7270/Q2FB56MJ
TBA					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM50065454 (CHEBI:63453 \| CHEMBL3348846) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	5.10E+6	n/a	n/a
TBA					Assay Description Inhibition of wild-type FGFR4 (unknown origin) assessed as ratio of Kinact to Ki				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01019 BindingDB Entry DOI: 10.7270/Q2FB56MJ
TBA					More data for this Ligand-Target Pair