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Found 1 hit Enz. Inhib. hit(s) with Target = 'Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM14443'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Bos taurus (bovine))		BDBM14443
PNG
((1-{[4-(3-chlorophenyl)-1-methyl-2-oxo-1,2-dihydro...)
Show SMILES CC(=O)OC(c1cncn1Cc1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1)c1ccc(cc1)C#N
Show InChI InChI=1S/C30H23ClN4O3/c1-19(36)38-30(22-9-6-20(15-32)7-10-22)28-16-33-18-35(28)17-21-8-11-27-26(12-21)25(14-29(37)34(27)2)23-4-3-5-24(31)13-23/h3-14,16,18,30H,17H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...

Bioorg Med Chem Lett 15: 2033-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.062
BindingDB Entry DOI: 10.7270/Q23J3B61
More data for this
Ligand-Target Pair