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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM50112384'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50112384
PNG
(1-(3-Chloro-phenyl)-4-[3-(2'-methoxy-4'-trifluorom...)
Show SMILES COc1cc(ccc1-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cc1)C(F)(F)F
Show InChI InChI=1S/C29H26ClF3N4O2/c1-39-27-13-22(29(31,32)33)9-10-26(27)21-7-5-20(6-8-21)16-36-19-34-15-25(36)17-35-11-12-37(28(38)18-35)24-4-2-3-23(30)14-24/h2-10,13-15,19H,11-12,16-18H2,1H3
PDB

KEGG

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PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.86E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.

Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair