Found 2 hits Enz. Inhib. hit(s) with Target = 'Glucagon receptor' and Ligand = 'BDBM50059352' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucagon receptor
(Rattus norvegicus) | BDBM50059352
(CHEMBL442499 | [des-His1, Trp6, Glu9] glucagon-NH2)Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O Show InChI InChI=1S/C150H222N42O47S/c1-70(2)53-97(133(224)174-96(48-52-240-11)132(223)182-104(60-113(156)205)142(233)191-119(74(8)197)122(157)213)177-137(228)102(58-80-63-164-87-27-17-15-25-84(80)87)181-130(221)94(42-46-112(155)204)175-146(237)118(72(5)6)190-140(231)101(55-77-23-13-12-14-24-77)180-138(229)105(61-116(209)210)183-129(220)93(41-45-111(154)203)168-123(214)73(7)167-126(217)90(30-21-50-162-149(158)159)170-127(218)91(31-22-51-163-150(160)161)172-144(235)108(68-195)187-139(230)106(62-117(211)212)184-134(225)98(54-71(3)4)176-135(226)99(56-78-32-36-82(200)37-33-78)178-128(219)89(29-19-20-49-151)171-143(234)107(67-194)186-136(227)100(57-79-34-38-83(201)39-35-79)179-131(222)95(43-47-115(207)208)173-145(236)109(69-196)188-148(239)121(76(10)199)192-141(232)103(59-81-64-165-88-28-18-16-26-85(81)88)185-147(238)120(75(9)198)189-114(206)65-166-125(216)92(40-44-110(153)202)169-124(215)86(152)66-193/h12-18,23-28,32-39,63-64,70-76,86,89-109,118-121,164-165,193-201H,19-22,29-31,40-62,65-69,151-152H2,1-11H3,(H2,153,202)(H2,154,203)(H2,155,204)(H2,156,205)(H2,157,213)(H,166,216)(H,167,217)(H,168,214)(H,169,215)(H,170,218)(H,171,234)(H,172,235)(H,173,236)(H,174,224)(H,175,237)(H,176,226)(H,177,228)(H,178,219)(H,179,222)(H,180,229)(H,181,221)(H,182,223)(H,183,220)(H,184,225)(H,185,238)(H,186,227)(H,187,230)(H,188,239)(H,189,206)(H,190,231)(H,191,233)(H,192,232)(H,207,208)(H,209,210)(H,211,212)(H4,158,159,162)(H4,160,161,163)/t73-,74+,75+,76+,86-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,118-,119-,120-,121-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity towards Glucagon receptor in rat liver plasma membranes by displacement of 125 I-labelled glucagon |
J Med Chem 40: 2555-62 (1997)
Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50059352
(CHEMBL442499 | [des-His1, Trp6, Glu9] glucagon-NH2)Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O Show InChI InChI=1S/C150H222N42O47S/c1-70(2)53-97(133(224)174-96(48-52-240-11)132(223)182-104(60-113(156)205)142(233)191-119(74(8)197)122(157)213)177-137(228)102(58-80-63-164-87-27-17-15-25-84(80)87)181-130(221)94(42-46-112(155)204)175-146(237)118(72(5)6)190-140(231)101(55-77-23-13-12-14-24-77)180-138(229)105(61-116(209)210)183-129(220)93(41-45-111(154)203)168-123(214)73(7)167-126(217)90(30-21-50-162-149(158)159)170-127(218)91(31-22-51-163-150(160)161)172-144(235)108(68-195)187-139(230)106(62-117(211)212)184-134(225)98(54-71(3)4)176-135(226)99(56-78-32-36-82(200)37-33-78)178-128(219)89(29-19-20-49-151)171-143(234)107(67-194)186-136(227)100(57-79-34-38-83(201)39-35-79)179-131(222)95(43-47-115(207)208)173-145(236)109(69-196)188-148(239)121(76(10)199)192-141(232)103(59-81-64-165-88-28-18-16-26-85(81)88)185-147(238)120(75(9)198)189-114(206)65-166-125(216)92(40-44-110(153)202)169-124(215)86(152)66-193/h12-18,23-28,32-39,63-64,70-76,86,89-109,118-121,164-165,193-201H,19-22,29-31,40-62,65-69,151-152H2,1-11H3,(H2,153,202)(H2,154,203)(H2,155,204)(H2,156,205)(H2,157,213)(H,166,216)(H,167,217)(H,168,214)(H,169,215)(H,170,218)(H,171,234)(H,172,235)(H,173,236)(H,174,224)(H,175,237)(H,176,226)(H,177,228)(H,178,219)(H,179,222)(H,180,229)(H,181,221)(H,182,223)(H,183,220)(H,184,225)(H,185,238)(H,186,227)(H,187,230)(H,188,239)(H,189,206)(H,190,231)(H,191,233)(H,192,232)(H,207,208)(H,209,210)(H,211,212)(H4,158,159,162)(H4,160,161,163)/t73-,74+,75+,76+,86-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,118-,119-,120-,121-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 562 | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
pA2 value against Glucagon Receptor |
J Med Chem 40: 2555-62 (1997)
Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ |
More data for this
Ligand-Target Pair | |
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