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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Glucocorticoid receptor' and Ligand = 'BDBM50265766'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50265766
PNG
(CHEMBL4060190)
Show SMILES Cn1ccc(n1)S(=O)(=O)N1CCC2=Cc3c(C[C@@]2(C1)C(=O)c1cc(ccn1)C(F)(F)F)cnn3-c1ccc(F)cc1 |r,t:13|
Show InChI InChI=1S/C27H22F4N6O3S/c1-35-10-8-24(34-35)41(39,40)36-11-7-18-13-23-17(15-33-37(23)21-4-2-20(28)3-5-21)14-26(18,16-36)25(38)22-12-19(6-9-32-22)27(29,30)31/h2-6,8-10,12-13,15H,7,11,14,16H2,1H3/t26-/m0/s1
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PC cid
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Similars
Article
PubMed
 6.60n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor in human HepG2 cells assessed as inhibition of dexamethasone-induced tyrosine amino transferase activi...

J Med Chem 60: 3405-3421 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00162
BindingDB Entry DOI: 10.7270/Q27083X5
More data for this
Ligand-Target Pair