Found 7 hits Enz. Inhib. hit(s) with Target = 'Glutamate receptor 3' and Ligand = 'BDBM50060635' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glutamate receptor 3
(RAT) | BDBM50060635
((S)-2-Amino-3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-p...)Show InChI InChI=1S/C7H8FN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SIBIA Neurosciences, Inc.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 285: 358-70 (1998)
BindingDB Entry DOI: 10.7270/Q23R0RDM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor 3
(RAT) | BDBM50060635
((S)-2-Amino-3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-p...)Show InChI InChI=1S/C7H8FN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| 70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
European Research Centre for Drug Discovery and Development (NatSynDrugs)
Curated by ChEMBL
| Assay Description Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cells |
J Med Chem 51: 6614-8 (2008)
Article DOI: 10.1021/jm800865a BindingDB Entry DOI: 10.7270/Q261117R |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor 3
(Homo sapiens (Human)) | BDBM50060635
((S)-2-Amino-3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-p...)Show InChI InChI=1S/C7H8FN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB PubMed
| 179 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SIBIA Neurosciences, Inc.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 285: 358-70 (1998)
BindingDB Entry DOI: 10.7270/Q23R0RDM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor 3
(Homo sapiens (Human)) | BDBM50060635
((S)-2-Amino-3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-p...)Show InChI InChI=1S/C7H8FN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SIBIA Neurosciences, Inc.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 285: 358-70 (1998)
BindingDB Entry DOI: 10.7270/Q23R0RDM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor 3
(Homo sapiens (Human)) | BDBM50060635
((S)-2-Amino-3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-p...)Show InChI InChI=1S/C7H8FN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | n/a | n/a | 2.09E+4 | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Agonist activity at recombinant GluA3 receptor expressed in Xenopus oocytes |
Bioorg Med Chem 18: 1381-7 (2010)
Article DOI: 10.1016/j.bmc.2009.12.072 BindingDB Entry DOI: 10.7270/Q27W6CB2 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor 3
(RAT) | BDBM50060635
((S)-2-Amino-3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-p...)Show InChI InChI=1S/C7H8FN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 2.09E+4 | n/a | n/a | n/a | n/a |
European Research Centre for Drug Discovery and Development (NatSynDrugs)
Curated by ChEMBL
| Assay Description Agonist activity at cyclothiazide-desensitized rat recombinant flip iGluR3 expressed in Xenopus laevis oocytes by two electrode voltage-clamp electro... |
J Med Chem 51: 6614-8 (2008)
Article DOI: 10.1021/jm800865a BindingDB Entry DOI: 10.7270/Q261117R |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor 3
(Homo sapiens (Human)) | BDBM50060635
((S)-2-Amino-3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-p...)Show InChI InChI=1S/C7H8FN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | n/a | n/a | 2.09E+4 | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Agonist activity at recombinant GluA3 receptor flip isoform expressed in Xenopus oocytes |
Bioorg Med Chem 18: 1381-7 (2010)
Article DOI: 10.1016/j.bmc.2009.12.072 BindingDB Entry DOI: 10.7270/Q27W6CB2 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |