Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM135076'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM135076 (US8846698, 563) Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cn3cc(cn3)C(F)(F)F)c2)c2cnc(N)nc12 Show InChI InChI=1S/C22H21F3N8O3/c1-21(2,11-34)33-9-16(15-7-28-20(26)31-19(15)33)18(36)12-3-14(6-27-4-12)30-17(35)10-32-8-13(5-29-32)22(23,24)25/h3-9,34H,10-11H2,1-2H3,(H,30,35)(H2,26,28,31)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.11	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Limited US Patent					Assay Description Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...				US Patent US8846698 (2014) BindingDB Entry DOI: 10.7270/Q2F47MTW
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