Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM356226'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM356226 (N-(2-((2,4-dioxo-3,4- dihydropyrimidin-1(2H)- yl)m...) Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cnc(Cn3ccc(=O)[nH]c3=O)nc2-c2ccccc2)c(F)cc1C(F)(F)F Show InChI InChI=1S/C27H19F4N7O3/c1-37-9-7-20(36-37)16-11-17(19(28)12-18(16)27(29,30)31)25(40)33-21-13-32-22(14-38-10-8-23(39)35-26(38)41)34-24(21)15-5-3-2-4-6-15/h2-13H,14H2,1H3,(H,33,40)(H,35,39,41)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.350	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...				US Patent US9815846 (2017) BindingDB Entry DOI: 10.7270/Q20P129R
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