BindingDB PrimarySearch

Found 10 hits Enz. Inhib. hit(s) with Target = 'Histamine H3 receptor' and Ligand = 'BDBM50215536'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histamine H3 receptor (GUINEA PIG)	BDBM50215536 ((R)-Alpha-Methylhistamine \| CHEBI:73337 \| CHEMBL26...) Show SMILES C[C@@H](N)Cc1c[nH]cn1 \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	0.0851	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The James Black Foundation Curated by ChEMBL					Assay Description Binding affinity towards histamine H3 receptor using [3H](R)-alpha-methylhistamine as radioligand in guinea pig cortical homogenates				Bioorg Med Chem Lett 9: 1825-30 (1999) BindingDB Entry DOI: 10.7270/Q24T6MKG
The James Black Foundation Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50215536 ((R)-Alpha-Methylhistamine \| CHEBI:73337 \| CHEMBL26...) Show SMILES C[C@@H](N)Cc1c[nH]cn1 \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	0.151	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The James Black Foundation Curated by ChEMBL					Assay Description Binding affinity towards histamine H3 receptor using [3H](R)-alpha-methylhistamine as radioligand in guinea pig ileum LMMP homogenates				Bioorg Med Chem Lett 9: 1825-30 (1999) BindingDB Entry DOI: 10.7270/Q24T6MKG
The James Black Foundation Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50215536 ((R)-Alpha-Methylhistamine \| CHEBI:73337 \| CHEMBL26...) Show SMILES C[C@@H](N)Cc1c[nH]cn1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	2.51	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description Affinity for histamine H3 receptor in rat cerebral cortex.				J Med Chem 42: 1193-202 (1999) Article DOI: 10.1021/jm980408v BindingDB Entry DOI: 10.7270/Q20Z760D
University of Kuopio Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50215536 ((R)-Alpha-Methylhistamine \| CHEBI:73337 \| CHEMBL26...) Show SMILES C[C@@H](N)Cc1c[nH]cn1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	4.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Curated by ChEMBL					Assay Description Inhibitory activity measured by [3H]- N alpha- methyl-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H3 receptor				J Med Chem 46: 5445-57 (2003) Article DOI: 10.1021/jm030905y BindingDB Entry DOI: 10.7270/Q2FN18X0
Vrije Universiteit Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50215536 ((R)-Alpha-Methylhistamine \| CHEBI:73337 \| CHEMBL26...) Show SMILES C[C@@H](N)Cc1c[nH]cn1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	6.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity in Nluc-hH3R assessed in HEK293T cells by NanoBRET binding assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01089 BindingDB Entry DOI: 10.7270/Q2TB1BTS
TBA					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50215536 ((R)-Alpha-Methylhistamine \| CHEBI:73337 \| CHEMBL26...) Show SMILES C[C@@H](N)Cc1c[nH]cn1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	6.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Displacement of [3H]Nalpha-methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells				Bioorg Med Chem Lett 20: 7191-9 (2010) Article DOI: 10.1016/j.bmcl.2010.10.041 BindingDB Entry DOI: 10.7270/Q2Q81GX5
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50215536 ((R)-Alpha-Methylhistamine \| CHEBI:73337 \| CHEMBL26...) Show SMILES C[C@@H](N)Cc1c[nH]cn1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	63	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity in Nluc-hH3R assessed in HEK293 cells by NanoBRET binding assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01089 BindingDB Entry DOI: 10.7270/Q2TB1BTS
TBA					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50215536 ((R)-Alpha-Methylhistamine \| CHEBI:73337 \| CHEMBL26...) Show SMILES C[C@@H](N)Cc1c[nH]cn1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.676	n/a	n/a	n/a	n/a
Vrije Universiteit Curated by ChEMBL					Assay Description Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine...				J Med Chem 46: 5445-57 (2003) Article DOI: 10.1021/jm030905y BindingDB Entry DOI: 10.7270/Q2FN18X0
Vrije Universiteit Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50215536 ((R)-Alpha-Methylhistamine \| CHEBI:73337 \| CHEMBL26...) Show SMILES C[C@@H](N)Cc1c[nH]cn1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.316	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Agonist activity at human histamine H3 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay				Bioorg Med Chem Lett 20: 7191-9 (2010) Article DOI: 10.1016/j.bmcl.2010.10.041 BindingDB Entry DOI: 10.7270/Q2Q81GX5
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50215536 ((R)-Alpha-Methylhistamine \| CHEBI:73337 \| CHEMBL26...) Show SMILES C[C@@H](N)Cc1c[nH]cn1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human H3 receptor expressed in HEK293 cells preincubated for 30 mins followed by [35S]-GTPgammaS addition and measured after 30 m...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112150 BindingDB Entry DOI: 10.7270/Q2C53QGV
TBA					More data for this Ligand-Target Pair