Found 3 hits Enz. Inhib. hit(s) with Target = 'Insulin-like growth factor 1 receptor' and Ligand = 'BDBM50158505' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50158505
(CHEMBL3786100)Show SMILES Nc1ncnc2n(cc(-c3cc(OCC45CCC(CC4)O5)ccc3F)c12)[C@@H]1C[C@H](CN2CC[S+]([O-])CC2)C1 |r,wD:26.30,28.33,(-1.03,2.79,;-1.03,1.55,;-2.38,.77,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,;1.76,-1.24,;2.66,.02,;1.76,1.24,;2.23,2.7,;3.76,2.91,;4.33,4.34,;5.86,4.56,;6.43,5.99,;7.96,6.21,;8.5,4.87,;10.02,4.88,;10.78,6.2,;9.99,7.52,;8.47,7.51,;9.19,6.61,;3.38,5.56,;1.86,5.34,;1.29,3.91,;.07,3.74,;.3,.77,;2.24,-2.7,;3.54,-3.45,;2.74,-4.76,;3.1,-6.25,;4.58,-6.69,;4.94,-8.18,;6.42,-8.61,;7.53,-7.55,;8.72,-7.9,;7.17,-6.05,;5.69,-5.62,;1.42,-3.96,)| Show InChI InChI=1S/C28H34FN5O3S/c29-24-2-1-21(36-16-28-5-3-20(37-28)4-6-28)13-22(24)23-15-34(27-25(23)26(30)31-17-32-27)19-11-18(12-19)14-33-7-9-38(35)10-8-33/h1-2,13,15,17-20H,3-12,14,16H2,(H2,30,31,32)/t18-,19+,20?,28? | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of full length IGF-1 receptor (unknown origin) transfected in Ba/F3 cells assessed as cell proliferation |
Bioorg Med Chem Lett 26: 2057-64 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.075 BindingDB Entry DOI: 10.7270/Q29K4D4J |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50158505
(CHEMBL3786100)Show SMILES Nc1ncnc2n(cc(-c3cc(OCC45CCC(CC4)O5)ccc3F)c12)[C@@H]1C[C@H](CN2CC[S+]([O-])CC2)C1 |r,wD:26.30,28.33,(-1.03,2.79,;-1.03,1.55,;-2.38,.77,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,;1.76,-1.24,;2.66,.02,;1.76,1.24,;2.23,2.7,;3.76,2.91,;4.33,4.34,;5.86,4.56,;6.43,5.99,;7.96,6.21,;8.5,4.87,;10.02,4.88,;10.78,6.2,;9.99,7.52,;8.47,7.51,;9.19,6.61,;3.38,5.56,;1.86,5.34,;1.29,3.91,;.07,3.74,;.3,.77,;2.24,-2.7,;3.54,-3.45,;2.74,-4.76,;3.1,-6.25,;4.58,-6.69,;4.94,-8.18,;6.42,-8.61,;7.53,-7.55,;8.72,-7.9,;7.17,-6.05,;5.69,-5.62,;1.42,-3.96,)| Show InChI InChI=1S/C28H34FN5O3S/c29-24-2-1-21(36-16-28-5-3-20(37-28)4-6-28)13-22(24)23-15-34(27-25(23)26(30)31-17-32-27)19-11-18(12-19)14-33-7-9-38(35)10-8-33/h1-2,13,15,17-20H,3-12,14,16H2,(H2,30,31,32)/t18-,19+,20?,28? | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of IGF-1 receptor (unknown origin) in presence of [gamma33P]ATP |
Bioorg Med Chem Lett 26: 2057-64 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.075 BindingDB Entry DOI: 10.7270/Q29K4D4J |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50158505
(CHEMBL3786100)Show SMILES Nc1ncnc2n(cc(-c3cc(OCC45CCC(CC4)O5)ccc3F)c12)[C@@H]1C[C@H](CN2CC[S+]([O-])CC2)C1 |r,wD:26.30,28.33,(-1.03,2.79,;-1.03,1.55,;-2.38,.77,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,;1.76,-1.24,;2.66,.02,;1.76,1.24,;2.23,2.7,;3.76,2.91,;4.33,4.34,;5.86,4.56,;6.43,5.99,;7.96,6.21,;8.5,4.87,;10.02,4.88,;10.78,6.2,;9.99,7.52,;8.47,7.51,;9.19,6.61,;3.38,5.56,;1.86,5.34,;1.29,3.91,;.07,3.74,;.3,.77,;2.24,-2.7,;3.54,-3.45,;2.74,-4.76,;3.1,-6.25,;4.58,-6.69,;4.94,-8.18,;6.42,-8.61,;7.53,-7.55,;8.72,-7.9,;7.17,-6.05,;5.69,-5.62,;1.42,-3.96,)| Show InChI InChI=1S/C28H34FN5O3S/c29-24-2-1-21(36-16-28-5-3-20(37-28)4-6-28)13-22(24)23-15-34(27-25(23)26(30)31-17-32-27)19-11-18(12-19)14-33-7-9-38(35)10-8-33/h1-2,13,15,17-20H,3-12,14,16H2,(H2,30,31,32)/t18-,19+,20?,28? | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of full length IGF-1 receptor (unknown origin) autophosphorylation transfected in HEK293 cells pretreated for 60 mins followed by IGF-1 st... |
Bioorg Med Chem Lett 26: 2057-64 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.075 BindingDB Entry DOI: 10.7270/Q29K4D4J |
More data for this Ligand-Target Pair | |