BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with Target = 'Insulin-like growth factor 1 receptor' and Ligand = 'BDBM50299148'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50299148 ((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
University of Arkansas for Medical Sciences Curated by ChEMBL					Assay Description Inhibition of IGF-1R (unknown origin)				J Med Chem 62: 1731-1760 (2019) Article DOI: 10.1021/acs.jmedchem.8b01092 BindingDB Entry DOI: 10.7270/Q29Z986G
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50299148 ((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co Curated by ChEMBL					Assay Description Inhibition of IGF1R after 60 mins by fluorescence electrophoresis				J Med Chem 52: 7360-3 (2009) Article DOI: 10.1021/jm900786r BindingDB Entry DOI: 10.7270/Q2P27022
Bristol-Myers Squibb Co Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50299148 ((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development Curated by ChEMBL					Assay Description Inhibition of IGF1R in IGF1R-SAL cells				Bioorg Med Chem Lett 20: 5027-30 (2010) Article DOI: 10.1016/j.bmcl.2010.07.045 BindingDB Entry DOI: 10.7270/Q2WH2Q5J
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50299148 ((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.40	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development Curated by ChEMBL					Assay Description Inhibition of IGF1R				Bioorg Med Chem Lett 20: 5027-30 (2010) Article DOI: 10.1016/j.bmcl.2010.07.045 BindingDB Entry DOI: 10.7270/Q2WH2Q5J
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Mus musculus)	BDBM50299148 ((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents Similars	MMDB Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co Curated by ChEMBL					Assay Description Inhibition of IGF1R phosphorylation in mouse Sal cells by western blotting				J Med Chem 52: 7360-3 (2009) Article DOI: 10.1021/jm900786r BindingDB Entry DOI: 10.7270/Q2P27022
Bristol-Myers Squibb Co Curated by ChEMBL					More data for this Ligand-Target Pair