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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Insulin-like growth factor 1 receptor' and Ligand = 'BDBM50340953'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))
BDBM50340953
PNG
(3-cyclobutyl-1-(quinolin-7-yl)imidazo[1,5-a]pyrazi...)
Show SMILES Nc1nccn2c(nc(-c3ccc4cccnc4c3)c12)C1CCC1
Show InChI InChI=1S/C19H17N5/c20-18-17-16(14-7-6-12-5-2-8-21-15(12)11-14)23-19(13-3-1-4-13)24(17)10-9-22-18/h2,5-11,13H,1,3-4H2,(H2,20,22)
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Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



OSI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length IGF1R expressed in mouse 3T3 cells


Bioorg Med Chem 16: 1359-75 (2008)


Article DOI: 10.1016/j.bmc.2007.10.061
BindingDB Entry DOI: 10.7270/Q2WH2QVH
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))
BDBM50340953
PNG
(3-cyclobutyl-1-(quinolin-7-yl)imidazo[1,5-a]pyrazi...)
Show SMILES Nc1nccn2c(nc(-c3ccc4cccnc4c3)c12)C1CCC1
Show InChI InChI=1S/C19H17N5/c20-18-17-16(14-7-6-12-5-2-8-21-15(12)11-14)23-19(13-3-1-4-13)24(17)10-9-22-18/h2,5-11,13H,1,3-4H2,(H2,20,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



OSI Pharmaceuticals, Inc

Curated by ChEMBL


Assay Description
Inhibition of IGF-1R by ELISA


Bioorg Med Chem Lett 21: 2092-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.139
BindingDB Entry DOI: 10.7270/Q23N23QH
More data for this
Ligand-Target Pair