Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Isoform 2 of Histone lysine demethylase PHF8 (2)' and Ligand = 'BDBM276067'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Isoform 2 of Histone lysine demethylase PHF8 (2) (Homo sapiens (Human))	BDBM276067 (2-[1-[(3-chloro-2-fluorophenyl)methyl]imidazol-4-y...) Show SMILES Fc1c(Cl)cccc1Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1 Show InChI InChI=1S/C17H12ClFN6/c18-13-3-1-2-12(17(13)19)8-25-9-16(21-10-25)14-6-11(4-5-20-14)15-7-22-24-23-15/h1-7,9-10H,8H2,(H,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	25
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...				US Patent US10071984 (2018) BindingDB Entry DOI: 10.7270/Q24Q7X0X
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