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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]' and Ligand = 'BDBM420252'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM420252
PNG
((3-Hydroxy-3-methylazetidin-1-yl)(7S)-4-[(6-methox...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CC(C)(O)C1 |r|
Show InChI InChI=1S/C23H24N6O3S/c1-23(31)10-28(11-23)22(30)13-3-4-15-18(7-13)33-21-19(15)20(24-12-25-21)27-16-8-14-5-6-26-29(14)9-17(16)32-2/h5-6,8-9,12-13,31H,3-4,7,10-11H2,1-2H3,(H,24,25,27)/t13-/m0/s1
PDB

UniProtKB/SwissProt

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US Patent
n/an/a<1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...

US Patent US10487092 (2019)


BindingDB Entry DOI: 10.7270/Q28W3GPZ
More data for this
Ligand-Target Pair