Found 13 hits Enz. Inhib. hit(s) with Target = 'Lutropin-choriogonadotropic hormone receptor' and Ligand = 'BDBM50505787' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Lutropin-choriogonadotropic hormone receptor
(Rattus norvegicus) | BDBM50505787
(CHEMBL4537998)Show SMILES Fc1ccc(Oc2ccc(NC(=O)N3CCc4ncccc4[C@@H]3c3ccc(Cl)cc3)cc2)cc1 |r| Show InChI InChI=1S/C27H21ClFN3O2/c28-19-5-3-18(4-6-19)26-24-2-1-16-30-25(24)15-17-32(26)27(33)31-21-9-13-23(14-10-21)34-22-11-7-20(29)8-12-22/h1-14,16,26H,15,17H2,(H,31,33)/t26-/m0/s1 | PDB
Reactome pathway
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| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer AG
Curated by ChEMBL
| Assay Description
Antagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-indu... |
J Med Chem 62: 10321-10341 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01382
BindingDB Entry DOI: 10.7270/Q29P34X6 |
More data for this
Ligand-Target Pair | |
Lutropin-choriogonadotropic hormone receptor
(Homo sapiens (Human)) | BDBM50505787
(CHEMBL4537998)Show SMILES Fc1ccc(Oc2ccc(NC(=O)N3CCc4ncccc4[C@@H]3c3ccc(Cl)cc3)cc2)cc1 |r| Show InChI InChI=1S/C27H21ClFN3O2/c28-19-5-3-18(4-6-19)26-24-2-1-16-30-25(24)15-17-32(26)27(33)31-21-9-13-23(14-10-21)34-22-11-7-20(29)8-12-22/h1-14,16,26H,15,17H2,(H,31,33)/t26-/m0/s1 | PDB
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| n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer AG
Curated by ChEMBL
| Assay Description
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed ... |
J Med Chem 62: 10321-10341 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01382
BindingDB Entry DOI: 10.7270/Q29P34X6 |
More data for this
Ligand-Target Pair | |
Lutropin-choriogonadotropic hormone receptor
(Homo sapiens (Human)) | BDBM50505787
(CHEMBL4537998)Show SMILES Fc1ccc(Oc2ccc(NC(=O)N3CCc4ncccc4[C@@H]3c3ccc(Cl)cc3)cc2)cc1 |r| Show InChI InChI=1S/C27H21ClFN3O2/c28-19-5-3-18(4-6-19)26-24-2-1-16-30-25(24)15-17-32(26)27(33)31-21-9-13-23(14-10-21)34-22-11-7-20(29)8-12-22/h1-14,16,26H,15,17H2,(H,31,33)/t26-/m0/s1 | PDB
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| n/a | n/a | 97 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer AG
Curated by ChEMBL
| Assay Description
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist ... |
J Med Chem 62: 10321-10341 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01382
BindingDB Entry DOI: 10.7270/Q29P34X6 |
More data for this
Ligand-Target Pair | |
Lutropin-choriogonadotropic hormone receptor
(Homo sapiens (Human)) | BDBM50505787
(CHEMBL4537998)Show SMILES Fc1ccc(Oc2ccc(NC(=O)N3CCc4ncccc4[C@@H]3c3ccc(Cl)cc3)cc2)cc1 |r| Show InChI InChI=1S/C27H21ClFN3O2/c28-19-5-3-18(4-6-19)26-24-2-1-16-30-25(24)15-17-32(26)27(33)31-21-9-13-23(14-10-21)34-22-11-7-20(29)8-12-22/h1-14,16,26H,15,17H2,(H,31,33)/t26-/m0/s1 | PDB
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| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer AG
Curated by ChEMBL
| Assay Description
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist ... |
J Med Chem 62: 10321-10341 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01382
BindingDB Entry DOI: 10.7270/Q29P34X6 |
More data for this
Ligand-Target Pair | |
Lutropin-choriogonadotropic hormone receptor
(Homo sapiens (Human)) | BDBM50505787
(CHEMBL4537998)Show SMILES Fc1ccc(Oc2ccc(NC(=O)N3CCc4ncccc4[C@@H]3c3ccc(Cl)cc3)cc2)cc1 |r| Show InChI InChI=1S/C27H21ClFN3O2/c28-19-5-3-18(4-6-19)26-24-2-1-16-30-25(24)15-17-32(26)27(33)31-21-9-13-23(14-10-21)34-22-11-7-20(29)8-12-22/h1-14,16,26H,15,17H2,(H,31,33)/t26-/m0/s1 | PDB
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| n/a | n/a | 650 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer AG
Curated by ChEMBL
| Assay Description
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 ... |
J Med Chem 62: 10321-10341 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01382
BindingDB Entry DOI: 10.7270/Q29P34X6 |
More data for this
Ligand-Target Pair | |
Lutropin-choriogonadotropic hormone receptor
(Homo sapiens (Human)) | BDBM50505787
(CHEMBL4537998)Show SMILES Fc1ccc(Oc2ccc(NC(=O)N3CCc4ncccc4[C@@H]3c3ccc(Cl)cc3)cc2)cc1 |r| Show InChI InChI=1S/C27H21ClFN3O2/c28-19-5-3-18(4-6-19)26-24-2-1-16-30-25(24)15-17-32(26)27(33)31-21-9-13-23(14-10-21)34-22-11-7-20(29)8-12-22/h1-14,16,26H,15,17H2,(H,31,33)/t26-/m0/s1 | PDB
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| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer AG
Curated by ChEMBL
| Assay Description
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 ... |
J Med Chem 62: 10321-10341 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01382
BindingDB Entry DOI: 10.7270/Q29P34X6 |
More data for this
Ligand-Target Pair | |
Lutropin-choriogonadotropic hormone receptor
(Homo sapiens (Human)) | BDBM50505787
(CHEMBL4537998)Show SMILES Fc1ccc(Oc2ccc(NC(=O)N3CCc4ncccc4[C@@H]3c3ccc(Cl)cc3)cc2)cc1 |r| Show InChI InChI=1S/C27H21ClFN3O2/c28-19-5-3-18(4-6-19)26-24-2-1-16-30-25(24)15-17-32(26)27(33)31-21-9-13-23(14-10-21)34-22-11-7-20(29)8-12-22/h1-14,16,26H,15,17H2,(H,31,33)/t26-/m0/s1 | PDB
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PC cid
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UniChem
| Article
PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer AG
Curated by ChEMBL
| Assay Description
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 ... |
J Med Chem 62: 10321-10341 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01382
BindingDB Entry DOI: 10.7270/Q29P34X6 |
More data for this
Ligand-Target Pair | |
Lutropin-choriogonadotropic hormone receptor
(Homo sapiens (Human)) | BDBM50505787
(CHEMBL4537998)Show SMILES Fc1ccc(Oc2ccc(NC(=O)N3CCc4ncccc4[C@@H]3c3ccc(Cl)cc3)cc2)cc1 |r| Show InChI InChI=1S/C27H21ClFN3O2/c28-19-5-3-18(4-6-19)26-24-2-1-16-30-25(24)15-17-32(26)27(33)31-21-9-13-23(14-10-21)34-22-11-7-20(29)8-12-22/h1-14,16,26H,15,17H2,(H,31,33)/t26-/m0/s1 | PDB
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| Article
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| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer AG
Curated by ChEMBL
| Assay Description
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 ... |
J Med Chem 62: 10321-10341 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01382
BindingDB Entry DOI: 10.7270/Q29P34X6 |
More data for this
Ligand-Target Pair | |
Lutropin-choriogonadotropic hormone receptor
(Homo sapiens (Human)) | BDBM50505787
(CHEMBL4537998)Show SMILES Fc1ccc(Oc2ccc(NC(=O)N3CCc4ncccc4[C@@H]3c3ccc(Cl)cc3)cc2)cc1 |r| Show InChI InChI=1S/C27H21ClFN3O2/c28-19-5-3-18(4-6-19)26-24-2-1-16-30-25(24)15-17-32(26)27(33)31-21-9-13-23(14-10-21)34-22-11-7-20(29)8-12-22/h1-14,16,26H,15,17H2,(H,31,33)/t26-/m0/s1 | PDB
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PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer AG
Curated by ChEMBL
| Assay Description
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 ... |
J Med Chem 62: 10321-10341 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01382
BindingDB Entry DOI: 10.7270/Q29P34X6 |
More data for this
Ligand-Target Pair | |
Lutropin-choriogonadotropic hormone receptor
(Homo sapiens (Human)) | BDBM50505787
(CHEMBL4537998)Show SMILES Fc1ccc(Oc2ccc(NC(=O)N3CCc4ncccc4[C@@H]3c3ccc(Cl)cc3)cc2)cc1 |r| Show InChI InChI=1S/C27H21ClFN3O2/c28-19-5-3-18(4-6-19)26-24-2-1-16-30-25(24)15-17-32(26)27(33)31-21-9-13-23(14-10-21)34-22-11-7-20(29)8-12-22/h1-14,16,26H,15,17H2,(H,31,33)/t26-/m0/s1 | PDB
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| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer AG
Curated by ChEMBL
| Assay Description
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist ... |
J Med Chem 62: 10321-10341 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01382
BindingDB Entry DOI: 10.7270/Q29P34X6 |
More data for this
Ligand-Target Pair | |
Lutropin-choriogonadotropic hormone receptor
(Homo sapiens (Human)) | BDBM50505787
(CHEMBL4537998)Show SMILES Fc1ccc(Oc2ccc(NC(=O)N3CCc4ncccc4[C@@H]3c3ccc(Cl)cc3)cc2)cc1 |r| Show InChI InChI=1S/C27H21ClFN3O2/c28-19-5-3-18(4-6-19)26-24-2-1-16-30-25(24)15-17-32(26)27(33)31-21-9-13-23(14-10-21)34-22-11-7-20(29)8-12-22/h1-14,16,26H,15,17H2,(H,31,33)/t26-/m0/s1 | PDB
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| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer AG
Curated by ChEMBL
| Assay Description
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist ... |
J Med Chem 62: 10321-10341 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01382
BindingDB Entry DOI: 10.7270/Q29P34X6 |
More data for this
Ligand-Target Pair | |
Lutropin-choriogonadotropic hormone receptor
(Homo sapiens (Human)) | BDBM50505787
(CHEMBL4537998)Show SMILES Fc1ccc(Oc2ccc(NC(=O)N3CCc4ncccc4[C@@H]3c3ccc(Cl)cc3)cc2)cc1 |r| Show InChI InChI=1S/C27H21ClFN3O2/c28-19-5-3-18(4-6-19)26-24-2-1-16-30-25(24)15-17-32(26)27(33)31-21-9-13-23(14-10-21)34-22-11-7-20(29)8-12-22/h1-14,16,26H,15,17H2,(H,31,33)/t26-/m0/s1 | PDB
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| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer AG
Curated by ChEMBL
| Assay Description
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist ... |
J Med Chem 62: 10321-10341 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01382
BindingDB Entry DOI: 10.7270/Q29P34X6 |
More data for this
Ligand-Target Pair | |
Lutropin-choriogonadotropic hormone receptor
(Homo sapiens (Human)) | BDBM50505787
(CHEMBL4537998)Show SMILES Fc1ccc(Oc2ccc(NC(=O)N3CCc4ncccc4[C@@H]3c3ccc(Cl)cc3)cc2)cc1 |r| Show InChI InChI=1S/C27H21ClFN3O2/c28-19-5-3-18(4-6-19)26-24-2-1-16-30-25(24)15-17-32(26)27(33)31-21-9-13-23(14-10-21)34-22-11-7-20(29)8-12-22/h1-14,16,26H,15,17H2,(H,31,33)/t26-/m0/s1 | PDB
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| n/a | n/a | n/a | n/a | >1.60E+4 | n/a | n/a | n/a | n/a |
Bayer AG
Curated by ChEMBL
| Assay Description
Agonist activity at human luteinizing hormone receptor incubated for 60 mins by cell based TR-FRET assay |
J Med Chem 62: 10321-10341 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01382
BindingDB Entry DOI: 10.7270/Q29P34X6 |
More data for this
Ligand-Target Pair | |
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