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Found 1 hit Enz. Inhib. hit(s) with Target = 'Macrophage colony-stimulating factor 1 receptor' and Ligand = 'BDBM50255880'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255880
PNG
(CHEMBL4076405)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCC(CC4)N(C)C)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C34H43FN8O3/c1-6-31(44)41-16-13-26(21-41)43-32-23(20-42(34(43)45)30-18-27(46-5)8-9-28(30)35)19-36-33(38-32)37-24-7-10-29(22(2)17-24)40-14-11-25(12-15-40)39(3)4/h7-10,17-19,25-26H,6,11-16,20-21H2,1-5H3,(H,36,37,38)/t26-/m0/s1
PDB

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PC cid
PC sid
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Similars
Article
PubMed
n/an/a 4.70n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair