Found 2 hits Enz. Inhib. hit(s) with Target = 'Maternal embryonic leucine zipper kinase' and Ligand = 'BDBM177218' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Maternal embryonic leucine zipper kinase
(Homo sapiens (Human)) | BDBM177218
(US9120749, 584 | US9120749, 585)Show SMILES Oc1c(Cl)cc(cc1Cl)-c1ccc2ncc(C(=O)C3CC3)c(N[C@H]3CC[C@H](CN4CCCC4)CC3)c2c1 |r,wU:23.24,wD:26.28,(-7.44,-.41,;-6.1,-1.18,;-6.1,-2.72,;-7.44,-3.49,;-4.77,-3.49,;-3.44,-2.72,;-3.44,-1.18,;-4.77,-.41,;-4.77,1.13,;-2.1,-3.49,;-2.1,-5.03,;-.77,-5.8,;.56,-5.03,;1.9,-5.8,;3.23,-5.03,;3.23,-3.49,;4.56,-2.72,;4.56,-1.18,;5.9,-3.49,;6.67,-4.83,;7.44,-3.49,;1.9,-2.72,;1.9,-1.18,;.56,-.41,;-.77,-1.18,;-2.1,-.41,;-2.1,1.13,;-3.44,1.9,;-3.44,3.44,;-2.19,4.34,;-2.67,5.8,;-4.21,5.8,;-4.68,4.34,;-.77,1.9,;.56,1.13,;.56,-3.49,;-.77,-2.72,)| Show InChI InChI=1S/C30H33Cl2N3O2/c31-25-14-21(15-26(32)30(25)37)20-7-10-27-23(13-20)28(24(16-33-27)29(36)19-5-6-19)34-22-8-3-18(4-9-22)17-35-11-1-2-12-35/h7,10,13-16,18-19,22,37H,1-6,8-9,11-12,17H2,(H,33,34)/t18-,22- | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | 7.4 | 25 |
ONCOTHERAPY SCIENCE, INC.
US Patent
| Assay Description MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ... |
US Patent US9120749 (2015)
BindingDB Entry DOI: 10.7270/Q2FX7872 |
More data for this Ligand-Target Pair | |
Maternal embryonic leucine zipper kinase
(Homo sapiens (Human)) | BDBM177218
(US9120749, 584 | US9120749, 585)Show SMILES Oc1c(Cl)cc(cc1Cl)-c1ccc2ncc(C(=O)C3CC3)c(N[C@H]3CC[C@H](CN4CCCC4)CC3)c2c1 |r,wU:23.24,wD:26.28,(-7.44,-.41,;-6.1,-1.18,;-6.1,-2.72,;-7.44,-3.49,;-4.77,-3.49,;-3.44,-2.72,;-3.44,-1.18,;-4.77,-.41,;-4.77,1.13,;-2.1,-3.49,;-2.1,-5.03,;-.77,-5.8,;.56,-5.03,;1.9,-5.8,;3.23,-5.03,;3.23,-3.49,;4.56,-2.72,;4.56,-1.18,;5.9,-3.49,;6.67,-4.83,;7.44,-3.49,;1.9,-2.72,;1.9,-1.18,;.56,-.41,;-.77,-1.18,;-2.1,-.41,;-2.1,1.13,;-3.44,1.9,;-3.44,3.44,;-2.19,4.34,;-2.67,5.8,;-4.21,5.8,;-4.68,4.34,;-.77,1.9,;.56,1.13,;.56,-3.49,;-.77,-2.72,)| Show InChI InChI=1S/C30H33Cl2N3O2/c31-25-14-21(15-26(32)30(25)37)20-7-10-27-23(13-20)28(24(16-33-27)29(36)19-5-6-19)34-22-8-3-18(4-9-22)17-35-11-1-2-12-35/h7,10,13-16,18-19,22,37H,1-6,8-9,11-12,17H2,(H,33,34)/t18-,22- | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | 7.4 | 25 |
ONCOTHERAPY SCIENCE, INC.
US Patent
| Assay Description MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ... |
US Patent US9120749 (2015)
BindingDB Entry DOI: 10.7270/Q2FX7872 |
More data for this Ligand-Target Pair | |