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Found 1 hit Enz. Inhib. hit(s) with Target = 'Matrix metalloproteinase-14' and Ligand = 'BDBM50348649'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Matrix metalloproteinase-14


(Homo sapiens (Human))		BDBM50348649
PNG
(CHEMBL1801393)
Show SMILES ONC(=O)C1(CCN(Cc2cccnc2)CC1)S(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C25H24F3N3O6S/c26-25(27,28)37-21-5-3-19(4-6-21)36-20-7-9-22(10-8-20)38(34,35)24(23(32)30-33)11-14-31(15-12-24)17-18-2-1-13-29-16-18/h1-10,13,16,33H,11-12,14-15,17H2,(H,30,32)
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Article
PubMed
n/an/a 3.70n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP14 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay

J Med Chem 53: 6653-80 (2010)


Article DOI: 10.1021/jm100669j
BindingDB Entry DOI: 10.7270/Q2KH0NQB
More data for this
Ligand-Target Pair