Found 8 hits Enz. Inhib. hit(s) with Target = 'Melatonin receptor type 1B' and Ligand = 'BDBM85065' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Melatonin receptor type 1B
(Homo sapiens (Human)) | BDBM85065
(CAS_117946-91-5 | Luzindole | NSC_122162)Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22) | PDB
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| Article
PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The German University in Cairo
Curated by ChEMBL
| Assay Description
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells |
J Med Chem 57: 3161-85 (2014)
Article DOI: 10.1021/jm401343c
BindingDB Entry DOI: 10.7270/Q218381K |
More data for this
Ligand-Target Pair | |
Melatonin receptor type 1B
(Homo sapiens (Human)) | BDBM85065
(CAS_117946-91-5 | Luzindole | NSC_122162)Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22) | PDB
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| Article
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| 10.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 355: 365-75 (1997)
Article DOI: 10.1007/pl00004956
BindingDB Entry DOI: 10.7270/Q2416VKF |
More data for this
Ligand-Target Pair | |
Melatonin receptor type 1B
(Homo sapiens (Human)) | BDBM85065
(CAS_117946-91-5 | Luzindole | NSC_122162)Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22) | PDB
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| Article
PubMed
| 11.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit&agrove; degli Studi di Milano
Curated by PDSP Ki Database
| |
Br J Pharmacol 127: 1288-94 (1999)
Article DOI: 10.1038/sj.bjp.0702658
BindingDB Entry DOI: 10.7270/Q20G3HQ6 |
More data for this
Ligand-Target Pair | |
Melatonin receptor type 1B
(Homo sapiens (Human)) | BDBM85065
(CAS_117946-91-5 | Luzindole | NSC_122162)Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22) | PDB
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| PubMed
| 14.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 285: 1239-45 (1998)
BindingDB Entry DOI: 10.7270/Q2PK0DPM |
More data for this
Ligand-Target Pair | |
Melatonin receptor type 1B
(Homo sapiens (Human)) | BDBM85065
(CAS_117946-91-5 | Luzindole | NSC_122162)Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22) | PDB
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| Article
PubMed
| 26.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
King's College London
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 358: 522-8 (1998)
Article DOI: 10.1007/pl00005288
BindingDB Entry DOI: 10.7270/Q2WW7G6S |
More data for this
Ligand-Target Pair | |
Melatonin receptor type 1B
(Homo sapiens (Human)) | BDBM85065
(CAS_117946-91-5 | Luzindole | NSC_122162)Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22) | PDB
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| PubMed
| 44.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
King's College London
Curated by ChEMBL
| Assay Description
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assa... |
J Med Chem 43: 1050-61 (2000)
BindingDB Entry DOI: 10.7270/Q2VQ33DC |
More data for this
Ligand-Target Pair | |
Melatonin receptor type 1B
(Homo sapiens (Human)) | BDBM85065
(CAS_117946-91-5 | Luzindole | NSC_122162)Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22) | PDB
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| PubMed
| 251 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 285: 1239-45 (1998)
BindingDB Entry DOI: 10.7270/Q2PK0DPM |
More data for this
Ligand-Target Pair | |
Melatonin receptor type 1B
(Chick) | BDBM85065
(CAS_117946-91-5 | Luzindole | NSC_122162)Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22) | KEGG
UniProtKB/SwissProt
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PubMed
| 1.74E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
King's College London
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 358: 522-8 (1998)
Article DOI: 10.1007/pl00005288
BindingDB Entry DOI: 10.7270/Q2WW7G6S |
More data for this
Ligand-Target Pair | |
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