BindingDB PrimarySearch

Found 12 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 2' and Ligand = 'BDBM50062522'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50062522 ((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	3.13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Taisho Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008				J Med Chem 47: 4570-87 (2004) Article DOI: 10.1021/jm0400294 BindingDB Entry DOI: 10.7270/Q2GH9HFK
Taisho Pharmaceutical Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50062522 ((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB PubMed	4.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H]-LY459477 from recombinant human mGlu2 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...				Citation and Details BindingDB Entry DOI: 10.7270/Q2611419
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50062522 ((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB PubMed	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Antagonist potency against cloned Metabotropic glutamate receptor 2				J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q
The Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50062522 ((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Taisho Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-MGS0008 from mGluR2 expressed in CHO cells				Bioorg Med Chem 16: 4359-66 (2008) Article DOI: 10.1016/j.bmc.2008.02.066 BindingDB Entry DOI: 10.7270/Q2PG1SMM
Taisho Pharmaceutical Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50062522 ((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	7.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at human recombinant mGlu2 receptor stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as asse...				Citation and Details BindingDB Entry DOI: 10.7270/Q2611419
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50062522 ((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Antagonist activity at human mGLUR2 expressed in RGT cells assessed as inhibition of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced inhibi...				Bioorg Med Chem Lett 22: 1958-62 (2012) Article DOI: 10.1016/j.bmcl.2012.01.039 BindingDB Entry DOI: 10.7270/Q2T72JJ1
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50062522 ((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2				J Med Chem 41: 358-78 (1998) Article DOI: 10.1021/jm970498o BindingDB Entry DOI: 10.7270/Q2XP7423
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50062522 ((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	23.2	n/a	n/a	n/a	n/a	n/a	n/a
Taisho Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Concentration required to inhibit metabotropic glutamate receptor 2 activity of rat expressed in CHO cells				J Med Chem 47: 4570-87 (2004) Article DOI: 10.1021/jm0400294 BindingDB Entry DOI: 10.7270/Q2GH9HFK
Taisho Pharmaceutical Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50062522 ((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at human recombinant mGlu2 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...				Citation and Details BindingDB Entry DOI: 10.7270/Q2611419
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50062522 ((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Centro de Investigación Lilly, SA Curated by ChEMBL					Assay Description Antagonistic activity against metabotropic glutamate receptor 2 (mGluR2) was evaluated				Bioorg Med Chem Lett 8: 2849-54 (1999) BindingDB Entry DOI: 10.7270/Q2Z0379C
Centro de Investigación Lilly, SA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50062522 ((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Perugia Curated by ChEMBL					Assay Description Antagonistic activity against stimulation of GTP (gamma) 35 S binding by glutamate in membranes from CHO cells expressing human mGluR2				Bioorg Med Chem Lett 11: 3179-82 (2001) BindingDB Entry DOI: 10.7270/Q27M08H1
Universit£ di Perugia Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50062522 ((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Taisho Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Effective concentration for agonistic activity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells				J Med Chem 47: 4570-87 (2004) Article DOI: 10.1021/jm0400294 BindingDB Entry DOI: 10.7270/Q2GH9HFK
Taisho Pharmaceutical Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)