Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase 8' and Ligand = 'BDBM50173831'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50173831 (4-(3-chloro-4-fluorophenylamino)-6-(3-(4-methylpip...) Show SMILES CN1CCN(CCCNc2cc3c(Nc4ccc(F)c(Cl)c4)c(cnc3cn2)C#N)CC1 Show InChI InChI=1S/C23H25ClFN7/c1-31-7-9-32(10-8-31)6-2-5-27-22-12-18-21(15-29-22)28-14-16(13-26)23(18)30-17-3-4-20(25)19(24)11-17/h3-4,11-12,14-15H,2,5-10H2,1H3,(H,27,29)(H,28,30)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylation				Bioorg Med Chem Lett 15: 5288-92 (2005) Article DOI: 10.1016/j.bmcl.2005.08.029 BindingDB Entry DOI: 10.7270/Q2JS9Q0M
					More data for this Ligand-Target Pair