Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase kinase 4' and Ligand = 'BDBM299490'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM299490 (N-[3-(4-amino- pyrido[3,2-d] pyrimidin-6-yl)- 5-fl...) Show SMILES Nc1ncnc2ccc(nc12)-c1cc(F)cc(NC(=O)CC2CCCC2)c1 Show InChI InChI=1S/C20H20FN5O/c21-14-8-13(16-5-6-17-19(26-16)20(22)24-11-23-17)9-15(10-14)25-18(27)7-12-3-1-2-4-12/h5-6,8-12H,1-4,7H2,(H,25,27)(H2,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	107	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				J Med Chem 46: 3709-27 (2003) BindingDB Entry DOI: 10.7270/Q2VH5R4B
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM299490 (N-[3-(4-amino- pyrido[3,2-d] pyrimidin-6-yl)- 5-fl...) Show SMILES Nc1ncnc2ccc(nc12)-c1cc(F)cc(NC(=O)CC2CCCC2)c1 Show InChI InChI=1S/C20H20FN5O/c21-14-8-13(16-5-6-17-19(26-16)20(22)24-11-23-17)9-15(10-14)25-18(27)7-12-3-1-2-4-12/h5-6,8-12H,1-4,7H2,(H,25,27)(H2,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	107	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				US Patent US9592235 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JKX
					More data for this Ligand-Target Pair