Found 2 hits Enz. Inhib. hit(s) with Target = 'Monoacylglycerol lipase ABHD6' and Ligand = 'BDBM444474' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Monoacylglycerol lipase ABHD6
(Homo sapiens (Human)) | BDBM444474
(US10662159, Example 67 | US10662159, Example 68)Show SMILES Fc1ccc(cc1)C(OC1CC2(C1)CCN(C2)C(=O)OC(C(F)(F)F)C(F)(F)F)c1ccc(F)cc1 |(-8.79,-.56,;-7.25,-.56,;-6.48,-1.9,;-4.94,-1.9,;-4.17,-.56,;-4.94,.77,;-6.48,.77,;-2.63,-.56,;-1.86,.77,;-.32,.77,;.77,-.32,;1.86,.77,;.77,1.86,;2.76,2.02,;4.23,1.54,;4.23,,;2.76,-.48,;5.47,-.91,;5.31,-2.44,;6.88,-.28,;8.13,-1.18,;9.53,-.56,;10.94,.07,;8.91,.85,;10.16,-1.96,;7.97,-2.72,;7.81,-4.25,;6.43,-2.55,;9.5,-2.88,;-1.86,-1.9,;-.32,-1.9,;.45,-3.23,;-.32,-4.56,;.45,-5.9,;-1.86,-4.56,;-2.63,-3.23,)| Show InChI InChI=1S/C24H21F8NO3/c25-16-5-1-14(2-6-16)19(15-3-7-17(26)8-4-15)35-18-11-22(12-18)9-10-33(13-22)21(34)36-20(23(27,28)29)24(30,31)32/h1-8,18-20H,9-13H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
MAKSCIENTIFIC, LLC
US Patent
| Assay Description ABHD6: Certain compounds were tested for their ABHD6 and dual ABHD6/MGL inhibitory activity, which is expressed as % of inhibition or IC50 values. Th... |
US Patent US10662159 (2020)
BindingDB Entry DOI: 10.7270/Q2RB77NZ |
More data for this Ligand-Target Pair | |
Monoacylglycerol lipase ABHD6
(Homo sapiens (Human)) | BDBM444474
(US10662159, Example 67 | US10662159, Example 68)Show SMILES Fc1ccc(cc1)C(OC1CC2(C1)CCN(C2)C(=O)OC(C(F)(F)F)C(F)(F)F)c1ccc(F)cc1 |(-8.79,-.56,;-7.25,-.56,;-6.48,-1.9,;-4.94,-1.9,;-4.17,-.56,;-4.94,.77,;-6.48,.77,;-2.63,-.56,;-1.86,.77,;-.32,.77,;.77,-.32,;1.86,.77,;.77,1.86,;2.76,2.02,;4.23,1.54,;4.23,,;2.76,-.48,;5.47,-.91,;5.31,-2.44,;6.88,-.28,;8.13,-1.18,;9.53,-.56,;10.94,.07,;8.91,.85,;10.16,-1.96,;7.97,-2.72,;7.81,-4.25,;6.43,-2.55,;9.5,-2.88,;-1.86,-1.9,;-.32,-1.9,;.45,-3.23,;-.32,-4.56,;.45,-5.9,;-1.86,-4.56,;-2.63,-3.23,)| Show InChI InChI=1S/C24H21F8NO3/c25-16-5-1-14(2-6-16)19(15-3-7-17(26)8-4-15)35-18-11-22(12-18)9-10-33(13-22)21(34)36-20(23(27,28)29)24(30,31)32/h1-8,18-20H,9-13H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MAKSCIENTIFIC, LLC
US Patent
| Assay Description ABHD6: Certain compounds were tested for their ABHD6 and dual ABHD6/MGL inhibitory activity, which is expressed as % of inhibition or IC50 values. Th... |
US Patent US10662159 (2020)
BindingDB Entry DOI: 10.7270/Q2RB77NZ |
More data for this Ligand-Target Pair | |