Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Multidrug resistance-associated protein 1 (Homo sapiens (Human)) | BDBM50295478 (1,16-Bis[40-((6-methyl)-4H-chromen-4-on-2-yl)pheny...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Hong Kong Polytechnic University Curated by ChEMBL | Assay Description Inhibition of MRP1 in human 2008/MRP1 cells by dixon plot analysis | J Med Chem 52: 5311-22 (2009) Article DOI: 10.1021/jm900194w BindingDB Entry DOI: 10.7270/Q25B02H5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Multidrug resistance-associated protein 1 (Homo sapiens (Human)) | BDBM50295478 (1,16-Bis[40-((6-methyl)-4H-chromen-4-on-2-yl)pheny...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Hong Kong Polytechnic University Curated by ChEMBL | Assay Description Inhibition of MRP1 in human 2008/MRP1 cells by Lineweaver-Burke plot analysis | J Med Chem 52: 5311-22 (2009) Article DOI: 10.1021/jm900194w BindingDB Entry DOI: 10.7270/Q25B02H5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Multidrug resistance-associated protein 1 (Homo sapiens (Human)) | BDBM50295478 (1,16-Bis[40-((6-methyl)-4H-chromen-4-on-2-yl)pheny...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 73 | n/a | n/a | n/a | n/a |
Hong Kong Polytechnic University Curated by ChEMBL | Assay Description Inhibition of MRP1 in human 2008/MRP1 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring reduction in cell survival afte... | J Med Chem 61: 9931-9951 (2018) Article DOI: 10.1021/acs.jmedchem.8b00834 BindingDB Entry DOI: 10.7270/Q2RX9FRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Multidrug resistance-associated protein 1 (Homo sapiens (Human)) | BDBM50295478 (1,16-Bis[40-((6-methyl)-4H-chromen-4-on-2-yl)pheny...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 111 | n/a | n/a | n/a | n/a |
Hong Kong Polytechnic University Curated by ChEMBL | Assay Description Inhibition of MRP1 (unknown origin) expressed in human 2008/MRP1 assessed as reversal of doxorubicin resistance after 5 days by MTS/PMS assay | J Med Chem 62: 8578-8608 (2019) Article DOI: 10.1021/acs.jmedchem.9b00963 BindingDB Entry DOI: 10.7270/Q28S4T5Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Multidrug resistance-associated protein 1 (Homo sapiens (Human)) | BDBM50295478 (1,16-Bis[40-((6-methyl)-4H-chromen-4-on-2-yl)pheny...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 73 | n/a | n/a | n/a | n/a |
The Hong Kong Polytechnic University Curated by ChEMBL | Assay Description Reversal of MRP1-mediated doxorubicin-resistance in human 2008/MRP1 cells assessed as reduction of doxorubicin IC50 percent by half | J Med Chem 52: 5311-22 (2009) Article DOI: 10.1021/jm900194w BindingDB Entry DOI: 10.7270/Q25B02H5 | |||||||||||
More data for this Ligand-Target Pair |