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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Muscarinic acetylcholine receptor M1' and Ligand = 'BDBM50135216'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50135216
PNG
(CHEMBL3747004)
Show SMILES Cc1cnc2c(cn(Cc3ccc(cc3)-c3ccn(C)n3)c2c1)C(=O)N[C@H]1CCOC[C@@H]1O |r|
Show InChI InChI=1S/C25H27N5O3/c1-16-11-22-24(26-12-16)19(25(32)27-21-8-10-33-15-23(21)31)14-30(22)13-17-3-5-18(6-4-17)20-7-9-29(2)28-20/h3-7,9,11-12,14,21,23,31H,8,10,13,15H2,1-2H3,(H,27,32)/t21-,23-/m0/s1
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Article
PubMed
n/an/an/an/a 211n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay

Bioorg Med Chem Lett 26: 650-5 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.053
BindingDB Entry DOI: 10.7270/Q29C708F
More data for this
Ligand-Target Pair