BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Muscarinic acetylcholine receptor M2' and Ligand = 'BDBM50525118'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50525118
PNG
(CHEMBL4567026)
Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc34)CC2)CC1 |r|
Show InChI InChI=1S/C46H68N10O7.3C2HF3O2/c1-31(2)29-38(52-43(60)32(3)49-46(63)37(50-33(4)57)16-17-41(47)58)45(62)48-20-24-54-27-25-53(26-28-54)21-10-9-11-34-18-22-55(23-19-34)30-42(59)56-39-14-7-5-12-35(39)44(61)51-36-13-6-8-15-40(36)56;3*3-2(4,5)1(6)7/h5-8,12-15,31-32,34,37-38H,9-11,16-30H2,1-4H3,(H2,47,58)(H,48,62)(H,49,63)(H,50,57)(H,51,61)(H,52,60);3*(H,6,7)/t32-,37-,38-;;;/m0.../s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 0.355n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method

J Med Chem 62: 5358-5369 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01967
BindingDB Entry DOI: 10.7270/Q25H7KQF
More data for this
Ligand-Target Pair