Found 9 hits Enz. Inhib. hit(s) with Target = 'N-acylethanolamine-hydrolyzing acid amidase' and Ligand = 'BDBM50151057' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
N-acylethanolamine-hydrolyzing acid amidase
(Homo sapiens (Human)) | BDBM50151057
(CHEMBL3770726)Show InChI InChI=1S/C14H24N2O3/c17-13-12(10-15-13)16-14(18)19-9-5-4-8-11-6-2-1-3-7-11/h11-12H,1-10H2,(H,15,17)(H,16,18)/t12-/m0/s1 | PDB
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of human NAAA |
J Med Chem 63: 7475-7490 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00191 BindingDB Entry DOI: 10.7270/Q2V98CM4 |
More data for this Ligand-Target Pair | |
N-acylethanolamine-hydrolyzing acid amidase
(Rattus norvegicus (Rat)) | BDBM50151057
(CHEMBL3770726)Show InChI InChI=1S/C14H24N2O3/c17-13-12(10-15-13)16-14(18)19-9-5-4-8-11-6-2-1-3-7-11/h11-12H,1-10H2,(H,15,17)(H,16,18)/t12-/m0/s1 | PDB
UniProtKB/SwissProt
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CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of rat NAAA |
J Med Chem 63: 7475-7490 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00191 BindingDB Entry DOI: 10.7270/Q2V98CM4 |
More data for this Ligand-Target Pair | |
N-acylethanolamine-hydrolyzing acid amidase
(Homo sapiens (Human)) | BDBM50151057
(CHEMBL3770726)Show InChI InChI=1S/C14H24N2O3/c17-13-12(10-15-13)16-14(18)19-9-5-4-8-11-6-2-1-3-7-11/h11-12H,1-10H2,(H,15,17)(H,16,18)/t12-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Italian Institute of Technology
Curated by ChEMBL
| Assay Description Inhibition of recombinant human NAAA expressed in HEK293 cells after 30 mins by UPLC/MS analysis |
Eur J Med Chem 111: 138-59 (2016)
Article DOI: 10.1016/j.ejmech.2016.01.046 BindingDB Entry DOI: 10.7270/Q2GQ70MX |
More data for this Ligand-Target Pair | |
N-acylethanolamine-hydrolyzing acid amidase
(Homo sapiens (Human)) | BDBM50151057
(CHEMBL3770726)Show InChI InChI=1S/C14H24N2O3/c17-13-12(10-15-13)16-14(18)19-9-5-4-8-11-6-2-1-3-7-11/h11-12H,1-10H2,(H,15,17)(H,16,18)/t12-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille
Curated by ChEMBL
| Assay Description Inhibition recombinant human NAAA expressed in HEK293 cells after 10 mins |
J Med Chem 60: 4-46 (2017)
Article DOI: 10.1021/acs.jmedchem.6b00538 BindingDB Entry DOI: 10.7270/Q2348NZC |
More data for this Ligand-Target Pair | |
N-acylethanolamine-hydrolyzing acid amidase
(Homo sapiens (Human)) | BDBM50151057
(CHEMBL3770726)Show InChI InChI=1S/C14H24N2O3/c17-13-12(10-15-13)16-14(18)19-9-5-4-8-11-6-2-1-3-7-11/h11-12H,1-10H2,(H,15,17)(H,16,18)/t12-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of recombinant human NAAA expressed in HEK cells |
J Med Chem 63: 7475-7490 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00191 BindingDB Entry DOI: 10.7270/Q2V98CM4 |
More data for this Ligand-Target Pair | |
N-acylethanolamine-hydrolyzing acid amidase
(Rattus norvegicus (Rat)) | BDBM50151057
(CHEMBL3770726)Show InChI InChI=1S/C14H24N2O3/c17-13-12(10-15-13)16-14(18)19-9-5-4-8-11-6-2-1-3-7-11/h11-12H,1-10H2,(H,15,17)(H,16,18)/t12-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto Italiano di Tecnologia
Curated by ChEMBL
| Assay Description Inhibition of rat NAAA expressed in HEK cells after 30 mins |
Eur J Med Chem 126: 561-575 (2017)
Article DOI: 10.1016/j.ejmech.2016.11.039 BindingDB Entry DOI: 10.7270/Q25H7JHB |
More data for this Ligand-Target Pair | |
N-acylethanolamine-hydrolyzing acid amidase
(Rattus norvegicus (Rat)) | BDBM50151057
(CHEMBL3770726)Show InChI InChI=1S/C14H24N2O3/c17-13-12(10-15-13)16-14(18)19-9-5-4-8-11-6-2-1-3-7-11/h11-12H,1-10H2,(H,15,17)(H,16,18)/t12-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille
Curated by ChEMBL
| Assay Description Inhibition of recombinant Sprague-Dawley rat NAAA expressed in HEK293 cells after 10 mins |
J Med Chem 60: 4-46 (2017)
Article DOI: 10.1021/acs.jmedchem.6b00538 BindingDB Entry DOI: 10.7270/Q2348NZC |
More data for this Ligand-Target Pair | |
N-acylethanolamine-hydrolyzing acid amidase
(Homo sapiens (Human)) | BDBM50151057
(CHEMBL3770726)Show InChI InChI=1S/C14H24N2O3/c17-13-12(10-15-13)16-14(18)19-9-5-4-8-11-6-2-1-3-7-11/h11-12H,1-10H2,(H,15,17)(H,16,18)/t12-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
Italian Institute of Technology
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human BRD4 bromodomain1 using H4KAc 5/8/12/16 peptide as substrate incubated overnight by HTRF assay |
Eur J Med Chem 111: 138-59 (2016)
Article DOI: 10.1016/j.ejmech.2016.01.046 BindingDB Entry DOI: 10.7270/Q2GQ70MX |
More data for this Ligand-Target Pair | |
N-acylethanolamine-hydrolyzing acid amidase
(Homo sapiens (Human)) | BDBM50151057
(CHEMBL3770726)Show InChI InChI=1S/C14H24N2O3/c17-13-12(10-15-13)16-14(18)19-9-5-4-8-11-6-2-1-3-7-11/h11-12H,1-10H2,(H,15,17)(H,16,18)/t12-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto Italiano di Tecnologia
Curated by ChEMBL
| Assay Description Inhibition of recombinant human NAAA expressed in HEK cells after 30 mins |
Eur J Med Chem 126: 561-575 (2017)
Article DOI: 10.1016/j.ejmech.2016.11.039 BindingDB Entry DOI: 10.7270/Q25H7JHB |
More data for this Ligand-Target Pair | |