BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'N-formyl peptide receptor 2' and Ligand = 'BDBM450307'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450307
PNG
(US10676431, Example 70 | US11117861, Example 70)
Show SMILES CP(C)(=O)c1c(F)cccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F |r|
Show InChI InChI=1S/C25H21ClF4N3O3P/c1-37(2,36)23-15(4-3-5-16(23)27)14-7-9-20(22(30)21(14)29)33-11-10-19(24(33)34)32-25(35)31-18-8-6-13(26)12-17(18)28/h3-9,12,19H,10-11H2,1-2H3,(H2,31,32,35)/t19-/m1/s1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.0770n/an/an/an/a


TBA

Assay Description
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2ZK5KV9
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450307
PNG
(US10676431, Example 70 | US11117861, Example 70)
Show SMILES CP(C)(=O)c1c(F)cccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F |r|
Show InChI InChI=1S/C25H21ClF4N3O3P/c1-37(2,36)23-15(4-3-5-16(23)27)14-7-9-20(22(30)21(14)29)33-11-10-19(24(33)34)32-25(35)31-18-8-6-13(26)12-17(18)28/h3-9,12,19H,10-11H2,1-2H3,(H2,31,32,35)/t19-/m1/s1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.0770n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)


BindingDB Entry DOI: 10.7270/Q2N58QFS
More data for this
Ligand-Target Pair