Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human)) | BDBM50228364 (3,4,5-trimethoxy-N-(2-(3-(piperazin-1-ylmethyl)imi...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 1.62E+4 | n/a | n/a | n/a | n/a | n/a |
Sirtris Pharmaceuticals Curated by ChEMBL | Assay Description Binding affinity to SIRT1 | J Med Chem 52: 1275-83 (2010) Article DOI: 10.1021/jm8012954 BindingDB Entry DOI: 10.7270/Q2ZC82V5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human)) | BDBM50228364 (3,4,5-trimethoxy-N-(2-(3-(piperazin-1-ylmethyl)imi...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a |
Sirtris Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Activation of human SIRT1 expressed in Escherichia coli BL21 by mass spectrometry assay | Nature 450: 712-716 (2007) Article DOI: 10.1038/nature06261 BindingDB Entry DOI: 10.7270/Q2765G67 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human)) | BDBM50228364 (3,4,5-trimethoxy-N-(2-(3-(piperazin-1-ylmethyl)imi...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 1.62E+4 | n/a | n/a | n/a | n/a | n/a |
Sirtris Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Binding affinity to human SIRT1 by isothermal titration calorimetry | Nature 450: 712-716 (2007) Article DOI: 10.1038/nature06261 BindingDB Entry DOI: 10.7270/Q2765G67 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human)) | BDBM50228364 (3,4,5-trimethoxy-N-(2-(3-(piperazin-1-ylmethyl)imi...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Activation of N-terminal His6-tagged SIRT1 (156 to 664 amino acid residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using ac-RHKKac-... | J Med Chem 56: 761-80 (2013) Article DOI: 10.1021/jm301032j BindingDB Entry DOI: 10.7270/Q2XP768M | |||||||||||
More data for this Ligand-Target Pair |