Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat)) | BDBM50093253 ((+)-3'-Methylspiro[1-azabicyclo[2.2.2]octane-3,5'-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Boston Curated by ChEMBL | Assay Description binding affinity in rat hippocampi against alpha7 nicotinic receptor | J Med Chem 43: 4045-50 (2000) BindingDB Entry DOI: 10.7270/Q24Q7T88 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat)) | BDBM50093253 ((+)-3'-Methylspiro[1-azabicyclo[2.2.2]octane-3,5'-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Boston Curated by ChEMBL | Assay Description binding affinity in rat hippocampi against alpha7 nicotinic receptor | J Med Chem 43: 4045-50 (2000) BindingDB Entry DOI: 10.7270/Q24Q7T88 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat)) | BDBM50093253 ((+)-3'-Methylspiro[1-azabicyclo[2.2.2]octane-3,5'-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | >3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Boston Curated by ChEMBL | Assay Description binding affinity in rat hippocampi against alpha7 nicotinic receptor | J Med Chem 43: 4045-50 (2000) BindingDB Entry DOI: 10.7270/Q24Q7T88 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat)) | BDBM50093253 ((+)-3'-Methylspiro[1-azabicyclo[2.2.2]octane-3,5'-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 6.00E+6 | n/a | n/a | n/a | n/a |
AstraZeneca R&D Boston Curated by ChEMBL | Assay Description Potency was determined by measuring current activation in Xenopus oocytes expressing rat alpha7 nAChRs | J Med Chem 43: 4045-50 (2000) BindingDB Entry DOI: 10.7270/Q24Q7T88 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat)) | BDBM50093253 ((+)-3'-Methylspiro[1-azabicyclo[2.2.2]octane-3,5'-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 6.00E+6 | n/a | n/a | n/a | n/a |
AstraZeneca R&D Boston Curated by ChEMBL | Assay Description Potency was determined by measuring current activation in Xenopus oocytes expressing rat alpha7 nAChRs | J Med Chem 43: 4045-50 (2000) BindingDB Entry DOI: 10.7270/Q24Q7T88 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM50093253 ((+)-3'-Methylspiro[1-azabicyclo[2.2.2]octane-3,5'-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR | J Med Chem 51: 6293-302 (2008) Article DOI: 10.1021/jm800607u BindingDB Entry DOI: 10.7270/Q2NZ88JP | |||||||||||
More data for this Ligand-Target Pair |