Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat)) | BDBM50161764 ((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universite Orleans Curated by ChEMBL | Assay Description Displacement of [125I]alpha-bungarotoxin from alpha7 nAchR in rat frontal cortices | Eur J Med Chem 107: 153-64 (2016) Article DOI: 10.1016/j.ejmech.2015.11.001 BindingDB Entry DOI: 10.7270/Q2TF01CW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat)) | BDBM50161764 ((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenates | J Med Chem 49: 4425-36 (2006) Article DOI: 10.1021/jm0602413 BindingDB Entry DOI: 10.7270/Q25B023S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat)) | BDBM50161764 ((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]MLA from alpha-7 nACh receptor in rat brain | Bioorg Med Chem Lett 18: 3611-5 (2008) Article DOI: 10.1016/j.bmcl.2008.04.070 BindingDB Entry DOI: 10.7270/Q2KD1ZS9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM50161764 ((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 24.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Displacement of [3H]-MLA from human alpha7 nAChR expressed in human SH-SY5Y cells | J Med Chem 53: 7192-201 (2010) Article DOI: 10.1021/jm100834y BindingDB Entry DOI: 10.7270/Q21J9C1V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM50161764 ((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago Curated by ChEMBL | Assay Description Agonist activity at alpha7 nAChR (unknown origin) | J Med Chem 57: 8204-23 (2014) Article DOI: 10.1021/jm401937a BindingDB Entry DOI: 10.7270/Q2KW5HPX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM50161764 ((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | n/a | n/a | n/a | n/a | 40 | n/a | n/a | 7.4 | 20 | |
UC San Diego | Assay Description Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 ul of 0.2 mg/ml an... | Taylor Research Group (2014) BindingDB Entry DOI: 10.7270/Q2DR2T3Z | |||||||||||
More data for this Ligand-Target Pair |