Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Nuclear factor NF-kappa-B p105 subunit' and Ligand = 'BDBM446463'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM446463 ((R)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-...) Show SMILES Cc1c(Nc2nc(nc3cc(CN4CC[C@@H](O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CCC(CC4)C(O)=O)cc(C#N)c3o2)c1C |r| Show InChI InChI=1S/C42H40F2N8O4/c1-23-30(5-3-7-32(23)41-49-35-16-25(15-28(18-45)37(35)56-41)20-51-12-9-27(10-13-51)42(54)55)31-6-4-8-33(24(31)2)47-39-36-34(48-40(50-39)38(43)44)17-26(19-46-36)21-52-14-11-29(53)22-52/h3-8,15-17,19,27,29,38,53H,9-14,20-22H2,1-2H3,(H,54,55)(H,47,48,50)/t29-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	55	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...				US Patent US10669271 (2020) BindingDB Entry DOI: 10.7270/Q2MG7SJC
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM446463 ((R)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-...) Show SMILES Cc1c(Nc2nc(nc3cc(CN4CC[C@@H](O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CCC(CC4)C(O)=O)cc(C#N)c3o2)c1C |r| Show InChI InChI=1S/C42H40F2N8O4/c1-23-30(5-3-7-32(23)41-49-35-16-25(15-28(18-45)37(35)56-41)20-51-12-9-27(10-13-51)42(54)55)31-6-4-8-33(24(31)2)47-39-36-34(48-40(50-39)38(43)44)17-26(19-46-36)21-52-14-11-29(53)22-52/h3-8,15-17,19,27,29,38,53H,9-14,20-22H2,1-2H3,(H,54,55)(H,47,48,50)/t29-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<10	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...				US Patent US10669271 (2020) BindingDB Entry DOI: 10.7270/Q2MG7SJC
					More data for this Ligand-Target Pair