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Found 1 hit Enz. Inhib. hit(s) with Target = 'Nuclear factor NF-kappa-B p105 subunit' and Ligand = 'BDBM446475'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nuclear factor NF-kappa-B p105 subunit


(Homo sapiens (Human))		BDBM446475
PNG
((R)-1-((7-cyano-2-(3′-(2-cyclopropyl-7-(((R)...)
Show SMILES Cc1c(Nc2nc(nc3cc(CN4CC[C@@H](O)C4)cnc23)C2CC2)cccc1-c1cccc(-c2nc3cc(CN4CC[C@H](C4)C(O)=O)cc(C#N)c3o2)c1C |r|
Show InChI InChI=1S/C43H42N8O4/c1-24-32(5-3-7-34(24)42-48-37-16-26(15-30(18-44)39(37)55-42)20-50-13-11-29(22-50)43(53)54)33-6-4-8-35(25(33)2)46-41-38-36(47-40(49-41)28-9-10-28)17-27(19-45-38)21-51-14-12-31(52)23-51/h3-8,15-17,19,28-29,31,52H,9-14,20-23H2,1-2H3,(H,53,54)(H,46,47,49)/t29-,31-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...

US Patent US10669271 (2020)


BindingDB Entry DOI: 10.7270/Q2MG7SJC
More data for this
Ligand-Target Pair