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Found 1 hit Enz. Inhib. hit(s) with Target = 'Orexin/Hypocretin receptor type 1' and Ligand = 'BDBM376840'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Orexin/Hypocretin receptor type 1


(Rattus norvegicus (Rat))		BDBM376840
PNG
(US9920038, 1)
Show SMILES Cc1oc(C[C@H]2CCCCN2C(=O)c2ccccc2-n2nccn2)nc1C(C)(C)O
Show InChI InChI=1S/C22H27N5O3/c1-15-20(22(2,3)29)25-19(30-15)14-16-8-6-7-13-26(16)21(28)17-9-4-5-10-18(17)27-23-11-12-24-27/h4-5,9-12,16,29H,6-8,13-14H2,1-3H3/t16-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



Montana State University



Assay Description
For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...

J Med Chem 50: 4928-38 (2007)


BindingDB Entry DOI: 10.7270/Q2VQ350T
More data for this
Ligand-Target Pair