Compile Data Set for Download or QSAR

Found 5 hits Enz. Inhib. hit(s) with Target = 'Orexin receptor type 2' and Ligand = 'BDBM118446'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM118446 (US11059828, Example 99 | US11667644, Example 99 | ...) Show SMILES Cc1cc(nc(n1)C(F)(F)F)N1CC2CN(CC2C1)C(=O)c1ccc(F)cc1-n1nccn1 Show InChI InChI=1S/C21H19F4N7O/c1-12-6-18(29-20(28-12)21(23,24)25)30-8-13-10-31(11-14(13)9-30)19(33)16-3-2-15(22)7-17(16)32-26-4-5-27-32/h2-7,13-14H,8-11H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica US Patent					Assay Description The in vitro affinity of the compounds for the human orexin-1 and orexin-2 receptors was determined by competitive radioligand binding using [3H]SB S...				US Patent US8653263 (2014) BindingDB Entry DOI: 10.7270/Q2BR8QV7
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM118446 (US11059828, Example 99 | US11667644, Example 99 | ...) Show SMILES Cc1cc(nc(n1)C(F)(F)F)N1CC2CN(CC2C1)C(=O)c1ccc(F)cc1-n1nccn1 Show InChI InChI=1S/C21H19F4N7O/c1-12-6-18(29-20(28-12)21(23,24)25)30-8-13-10-31(11-14(13)9-30)19(33)16-3-2-15(22)7-17(16)32-26-4-5-27-32/h2-7,13-14H,8-11H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PK0K9R
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM118446 (US11059828, Example 99 | US11667644, Example 99 | ...) Show SMILES Cc1cc(nc(n1)C(F)(F)F)N1CC2CN(CC2C1)C(=O)c1ccc(F)cc1-n1nccn1 Show InChI InChI=1S/C21H19F4N7O/c1-12-6-18(29-20(28-12)21(23,24)25)30-8-13-10-31(11-14(13)9-30)19(33)16-3-2-15(22)7-17(16)32-26-4-5-27-32/h2-7,13-14H,8-11H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars		15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2M330QS
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM118446 (US11059828, Example 99 | US11667644, Example 99 | ...) Show SMILES Cc1cc(nc(n1)C(F)(F)F)N1CC2CN(CC2C1)C(=O)c1ccc(F)cc1-n1nccn1 Show InChI InChI=1S/C21H19F4N7O/c1-12-6-18(29-20(28-12)21(23,24)25)30-8-13-10-31(11-14(13)9-30)19(33)16-3-2-15(22)7-17(16)32-26-4-5-27-32/h2-7,13-14H,8-11H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T156TJ
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM118446 (US11059828, Example 99 | US11667644, Example 99 | ...) Show SMILES Cc1cc(nc(n1)C(F)(F)F)N1CC2CN(CC2C1)C(=O)c1ccc(F)cc1-n1nccn1 Show InChI InChI=1S/C21H19F4N7O/c1-12-6-18(29-20(28-12)21(23,24)25)30-8-13-10-31(11-14(13)9-30)19(33)16-3-2-15(22)7-17(16)32-26-4-5-27-32/h2-7,13-14H,8-11H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	180	-38.5	n/a	n/a	n/a	n/a	n/a	n/a	25
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...				US Patent US9586962 (2017) BindingDB Entry DOI: 10.7270/Q27H1MN9
					More data for this Ligand-Target Pair