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Found 1 hit Enz. Inhib. hit(s) with Target = 'Parathyroid hormone/parathyroid hormone-related peptide receptor' and Ligand = 'BDBM50542598'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Parathyroid hormone/parathyroid hormone-related peptide receptor


(Homo sapiens (Human))		BDBM50542598
PNG
(CHEMBL4647898)
Show SMILES CC1(C)c2ncc(Cl)cc2-c2ccc(Cl)cc2N(c2ccc(NCCNC3CCOCC3)cc2)C1=O
Show InChI InChI=1S/C28H30Cl2N4O2/c1-28(2)26-24(15-19(30)17-33-26)23-8-3-18(29)16-25(23)34(27(28)35)22-6-4-20(5-7-22)31-11-12-32-21-9-13-36-14-10-21/h3-8,15-17,21,31-32H,9-14H2,1-2H3
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n/an/a 170n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at PTHR1 (unknown origin) expressed in CHOK1 cells co-expressing Gs/Gq assessed as reduction in human PTH (1 to 34 residues)-indu...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115524
BindingDB Entry DOI: 10.7270/Q2H135J0
More data for this
Ligand-Target Pair